［Abstract］　Objective　To establish a grading scheme that can guide surgical treatment and prognostic risk assessment by retrospective analysis of the data of the patients with skull-base tissue necrosis after radiotherapy for nasopharyngeal carcinoma. Methods　A total of 100 surgical cases of skull-base tissue necrosis after radiotherapy for nasopharyngeal carcinoma were enrolled into this study from Zhujiang Hospital, Southern Medical University and Guangdong Provincial People′s Hospital during January 2017 and January 2020. All the cases had been followed up with no recurrence. According to the imaging lesion sites, the difficulty of operative procedure, the risk of clinical surgery, combined with long-term clinical experience, a grading method based on the image data was proposed and the relationship between the different grades of lesions and the surgical effect and prognosis was analyzed. Results　The 100 cases enrolled in this study were classified into grade Ⅰ in 17 cases, grade Ⅱ in 30 cases, grade Ⅲ in 22 cases, grade Ⅳ in 26 cases and grade Ⅴ in 5 cases according to the proposed grading standards. The results of multiple logistic regression analysis showed that radiotherapy frequency［odds ratio(OR)=0.214, P=0.004) and CT grade(OR=19.371, P=0.022) were independent risk factors affecting the success rate of the surgery. Based on the standard of cure that we set, the total success rate of the surgery in this study was 71.00%, of which 88.24% for grade Ⅰ, 86.67% for grade Ⅱ, 68.18% for grade Ⅲ, 53.85% for grade Ⅳ(intranasal mucosal flap 47.62% and temporalis fascia flaps 80.00%) and 20.00% for grade Ⅴ(intranasal mucosal flap 0% and temporalis fascia flaps 100%). The median follow-up time was 10.29 months. Conclusion　A grading scheme is successfully established based on the imaging manifetations of skull-base tissue necrosis after radiotherapy for nasopharyngeal carcinoma, which can effectively assess the prognostic risk and guide the surgical treatment.]]> 2023/2/10 17:50:33 QIU Qian-hui, CHEN Hai-ling, CUI Yi, et al. 5true ［Abstract］　Objective　To explore the correlation between the distribution of Traditional Chinese Medicine(TCM) constitutional types and clinical pathological characteristics in patients with nasopharyngeal carcinoma(NPC), and to provide evidence for personalized TCM treatment for NPC. Methods　The clinical data of 58 NPC patients treated in the People′s Hospital of Guangxi Zhuang Autonomous Region were collected to analyze the relationship between TCM constitutional types and clinical characteristics in the NPC patients. Results　Among the 58 patients with newly diagnosed NPC, unbalanced constitution accounted for 68.97%(40/58). There was significant difference in the clinical stage distribution between the nasopharyngeal carcinoma patients with different TCM constitutional types(P<0.05). The Epstein-Barr virus-deoxyribonucleic acid(EBV-DNA) positivity rate tended to increase with increasing clinical stage. Thirteen cases achieved complete remission(CR) and 5 cases achieved partial remission(PR) at the end of treatment in the balanced constitution patients, and 21 cases achieved CR and 19 cases achieved PR in the unbalanced constitution patients, with no significant differences between the two groups of patients(Z=1.399, P=0.162). The 2-year disease-free survival rate was 100.00% in the balanced constitution patients and 81.20% in the unbalanced constitution patients, with no significant difference between the two groups of patients(P=0.068). Conclusion　Specific TCM constitutional types are correlated with the occurrence and development of NPC, and may change with the replication of EBV and the progression of the disease.]]> 2023/2/10 17:50:33 WENG Jing-jin, WEI Jia-zhang, WEI Yun-zhong, et al. 4true ［Abstract］　Eustachian tube dysfunction has a serious impact on patients with nasopharyngeal carcinoma, and the dysfunction is especially prevalent in patients with nasopharyngeal carcinoma after radiotherapy, affecting their quality of life. The evaluation and treatment of Eustachian tube dysfunction in the patients with nasopharyngeal carcinoma after radiotherapy are more complicated and difficult than those in the patients with Eustachian tube dysfunction caused by other diseases. This paper mainly reviews the relevant formation mechanism, evaluation and treatment systems, hoping to provide more references for the diagnosis and treatment of Eustachian tube dysfunction in nasopharyngeal carcinoma patients after radiotherapy.]]> 2023/2/10 17:50:33 LI Min, BAN Mo-lu, TANG Feng-zhu 3true ［Abstract］　Objective　To explore the diagnosis and treatment effect of physician-nurse collaboration in one-stop diagnosis and treatment on prognosis of patients with nasopharyngeal carcinoma carotid artery blowout syndrome. Methods　Three hundred and forty-nine patients with nasopharyngeal carcinoma admitted to the Third Affiliated Hospital of Southern Medical University from April 2018 to August 2022 were selected, among whom 288 patients were enrolled in this study and were divided into the observation group(221 cases) and the control group(67 cases). The observation group underwent the physician-nurse collaboration in one-stop diagnosis and treatment mode and the control group underwent the conventional diagnosis and treatment mode, and the diagnosis and treatment effect was compared between the two grops. Results　Compared with those in the control group, the treatment success rate of carotid artery blowout syndrome was significantly elevated, and the operation time was shortened, and the mortality was reduced, and the length of hospital stay was reduced, and the satisfaction of the doctors and nurses was improved in the observation group, with significant differences between the two groups(P<0.05). Conclusion　The physician-nurse collaboration in one-stop diagnosis and treatment can elevate the success rate of comprehensive treatment and the satisfaction of the doctors and nurses for patients with nasopharyngeal carcinoma carotid artery blowout syndrome, and shorten the operation time and hospital stay.]]> 2023/2/10 17:50:33 YANG Yi-mei, ZHENG Mei-yun, DING Yan-ping, et al. 2true ［Abstract］　Objective　To investigate the effects of Garcinone C on senescence, migration and invasion of nasopharyngeal carcinoma cells and their mechanisms of action. Methods　Nasopharyngeal carcinoma cells HONE1 were treated with Garcinone C and the senescent cells were detected by β-galactosidase staining. Transwell assay was used to detect the effects of Garcinone C intervention on the migration and invasion ability of nasopharyngeal carcinoma cells HONE1 and HK1. The expression levels of epithelial-mesenchymal transition(EMT) markers E-cadherin, N-cadherin and tissue inhibitor of matrix metalloproteinase 2(TIMP2), and the expression levels of iron death associated protein ferritin heavy chain 1(FTH1) and cystine transporter protein xCT in the nasopharyngeal carcinoma cells HONE1 and HK1 were detected by Western blot assay. Results　After the treatment of Garcinone C, the senescence rate of HONE1 cells increased(P<0.05), and the migration and invasion ability of HK1 and HONE1 cells decreased(P<0.05). Garcinone C intervention could up-regulate the expression levels of E-cadherin and TIMP2 proteins in HONE1 and HK1 cells(P<0.05), and could down-regulate the expression levels of N-cadherin, FTH1 and xCT proteins(P<0.05). Conclusion　Garcinone C may play a role in the treatment of nasopharyngeal carcinoma by inhibiting the migration and invasion of nasopharyngeal carcinoma cells and inducing their senescence and iron death, which has a promising application prospect.]]> 2023/2/10 17:50:33 ZHANG Han, WEI Dan, CAI Mei-ting, et al. 1true