［Abstract］　Objective　To analyze the application effect of hysteroscopic cold knife technique in day surgery. Methods　The clinical data of 2 159 patients with benign intrauterine diseases who were treated by hysteroscopic cold knife surgery in the Hysteroscopy Clinic of the People′s Hospital of Guangxi Zhuang Autonomous Region from July 20, 2020 to December 31, 2022 were retrospectively analyzed. The operation time, postoperative blood loss, one-time operation success rate, operation complications and pregnancy rate after operation were analyzed. Results　The 2 159 patients with benign intrauterine diseases were treated with hysteroscopic cold knife surgery, and the one-time operation success rate was 99.86%(2 156/2 159), and the postoperative blood loss was 0-10 ml. The postoperative complications occurred in 5 cases(including 1 case of uterine cavity mild adhesion after submucous myomectomy, 1 case of mild water intoxication after uterine mediastinal surgery, 1 case of postoperative massive bleeding one week after uterine mediastinal surgery, 1 case of uterine perforation during the operation of severe intrauterine adhesion, 1 case of uterine perforation caused by intrauterine device incarceration and removal of intrauterine device under hysteroscope. After aggressive treatment, all the patients were cured). Among the 2 159 patients, 80 patients with moderate to severe intrauterine adhesions who had fertility needs were follwed up, and the pregnancy rate was 47.50%(38/80). Conclusion　Within a certain range of indications, the cold knife technique can replace the traditional electrosurgical treatment of intrauterine benign diseases. The cold knife technique has the advantages of short learning curve, high success rate of one-time operation, low rate of complications, no electricity and heat damage, better protection of endometrium and female fertility, and is especially suitable for daytime operation.]]> 2023/2/28 12:21:57 LING Dan, ZHAO Ren-feng, LAI Li-kun, et al. 5true ［Abstract］　Hysteroscopy is considered as the gold standard for the diagnosis and treatment of intrauterine diseases. In recent years, hysteroscopic cold knife techniques have been widely used in the treatment of intrauterine diseases because they decrease the risk of endometrial trauma cause by the use of the resectoscope and have the protective effect on endometrium. This paper reviews the advantages and applications of various hysteroscopic cold knife techniques. In the process of applying hysteroscopic cold knife techniques, the doctors should formulate individualized treatment measures according to the specific condition of each patient, and choose the appropriate treatment method to achieve the best therapeutic effect.]]> 2023/2/28 12:21:57 YAN Yu-hua, LING Dan 4true ［Abstract］　Objective　To explore the clinical application value of hysteroscopic cold knife in the diagnosis and treatment of type Ⅰ cornual pregnancy. Methods　From February 2020 to February 2022, the clinical data of 8 patients who had the desire of fertility and were diagnosed with type Ⅰ cornual pregnancy by using three-dimensional vaginal ultrasound and hysteroscopy at the Third Affiliated Hospital of Zhengzhou University were retrospectively analyzed. All the patients underwent embryo removal by hysteroscopic cold knife surgery. The clearance of embryonic tissues in the uterine horn, intraoperative hemorrhage, whether laparoscopic monitoring was applied during the operation, whether the uterine horn was incised or excised during the surgery, the duration of the surgery, the trend of postoperative human chorionic gonadotropin(hCG) decline, and the postoperative uterine recovery were analyzed in the patients. Results　All the 8 patients underwent hysteroscopic surgery, and none of them suffered from water poisoning, massive bleeding and uterine perforation. The time for hCG to return to normal level after surgery was 3-6(4.00±1.07)weeks. Color ultrasonography was used to reexamine the uterus one month after surgery, and no embryonic residue was found in the uterine cavity. The recovery time of menstruation was 25-42(32.13±5.89)days and no intrauterine adhesions occurred. All the 8 cases had fertility requirements, among whom 1 case had normal delivery, and 3 cases were in the second trimester, and 4 cases were in a planned pregnancy during our follow-up period. Conclusion　Hysteroscopic cold knife can be used in the diagnosis and treatment of type Ⅰ cornual pregnancy, which can effectively protect the endometrium and is especially suitable for patients with fertility requirements.]]> 2023/2/28 12:21:57 QIAO Ming-jing, LUN Bing, SHI Kai-ge, et al. 3true ［Abstract］　Objective　To observe the clinical effects of two kinds of hysteroscopic cold knife on the treatment of moderate and severe intrauterine adhesions. Methods　A retrospective analysis was performed on 110 patients with moderate and severe intrauterine adhesions treated by cold-knife hysteroscopic surgery. The patients were divided into observation group and control group according to different treatment methods. The patients who underwent adhesion separation using non-dilatation cold-knife hysteroscopic system(Lingbao Integrated Mirror) were taken as the observation group(65 cases), while the patients who underwent adhesion separation using HEOS cold knife hysteroscopy were taken as the control group(45 cases). The intraoperative and postoperative related indicators were compared between the two groups. Results　The operation time of the observation group was shorter than that of the control group, and the intraoperative blood loss in the observation group was less than that in the control group, and the differences were statistically significant between the two groups(P<0.05). There was no significant difference in the uterine shape recovery after surgery between the two groups(P>0.05). The postoperative recovery of menstruation in the observation group was better than that in the control group and the difference was statistically significant between the two groups(P<0.05). The postoperative pregnancy rate of the observation group was higher than that of the control group, and the difference was statistically significant between the two groups(χ²=8.486, P=0.004). Conclusion　The non-dilatation integrated hysteroscope system has high surgical safety in the treatment of moderate and severe intrauterine adhesions. Compared with the HEOS cold knife hysteroscopy system, the non-dilatation integrated hysteroscope system has advantages of short operation time, less intraoperative blood loss, no dilatation and higher postoperative pregnancy rate.]]> 2023/2/28 0:00:00 TAN Lin, ZHOU Jing, QIU Le-le 2true ［Abstract］　Objective　To compare the clinical effects of two kinds of hysteroscopic surgery in resection of multiple endometrial polyps. Methods　The clinical data of 246 patients with multiple endometrial polyps admitted to Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital(Chengdu First People′s Hospital) from December 2020 to December 2021 were retrospectively analyzed, including 145 cases of hysteroscopic endometrial polypectomy(the electrosurgical group) and 101 cases of hysteroscopic cold knife resection(the cold knife group). The operation time, intraoperative blood loss, postoperative vaginal bleeding time and hospital stay were compared between the two groups. The postoperative complications, polyp recurrence and pregnancy outcomes were compared between the two groups after the patients were followed up for 1 year. Results　The operation time and the postoperative vaginal bleeding time in the cold knife group was longer than that in the electrosurgical group, but there was no significant difference between the two groups(P>0.05). There was no statistically significant difference in the postoperative recurrence rate between the two groups(15.84% vs 13.79%, P>0.05). The pregnancy rate after operation in the cold knife group was higher than that in the electrosurgical group, and the difference was significantly different between the two groups(25.74% vs 11.03%, P<0.05). There were no major complications such as pelvic infection and postoperative amenorrhea in the two groups after operation. Conclusion　Hysteroscopic cold knife resection is as safe and effective as traditional hysteroscopic electrotomy in the resection of multiple endometrial polyps. Although hysteroscopic cold knife resection may lengthen the operation time and the postoperative vaginal bleeding time, it can better protect the patients′ fertility.]]> 2023/2/28 12:21:57 ZHANG Li, CHEN Yan, HAN Jiao-jiao, et al. 1true