［Abstract］　After more than 30 years of development, non-invasive ventilation(NIV) has achieved good results in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD). NIV has become the first-line mechanical ventilation treatment for acute exacerbation of COPD. For the patients who have already undergone invasive ventilation with endotracheal intubation, NIV can effectively assist in the safe withdrawal of invasive ventilation. In the future, further research is needed on how to effectively connect NIV between hospitalization and home treatment.]]> 2025/3/1 12:31:00 CAO Zhixin 4true ［Abstract］　Chronic obstructive pulmonary disease(COPD) is a common chronic airway disease with high prevalence and heavy disease burden. With the application of metagenome detection technology, it has been found that the lungs contain low-biomass microbiota, and gut microbiota and lung microbiota have a potential connection through the “gut-lung axis”, and jointly participate in the development of COPD. Compared with healthy individuals, COPD patients have abnormal composition and function of lung microbiota and gut microbiota. Based on COPD and gut-lung microbiota interactions, the prevention and treatment of COPD by intervening the gut-lung microbiota have become a new therapeutic direction. In this paper, the distribution characteristics of gut-lung microbiota in COPD patients and the research progress of the mechanism of COPD and gut-lung microbiota interactions are summarized, providing new ideas for clinical diagnosis, treatment and research of COPD.]]> 2025/3/1 12:31:00 1, LI Aimin²]]> FENG Qiantong¹, LI Aimin² 3true ［Abstract］　Over the past decade, high-flow nasal cannula(HFNC) oxygen therapy has been widely applied in treatment of respiratory failure.Compared with conventional oxygen therapy(COT), HFNC oxygen therapy can maintain stable fraction of inspired oxygen(FiO₂), not only improve arterial oxygen partial pressure but also reduce arterial carbon dioxide partial pressure, decrease work of breathing, and improve diaphragmatic function. Clinical researches have confirmed that HFNC oxygen therapy is superior to COT in treating acute respiratory failure in chronic obstructive pulmonary disease(COPD). However, it remains controversial whether HFNC oxygen therapy is non-inferior to non-invasive ventilation(NIV). More large-scale, prospective, randomized controlled clinical trials are needed to optimize the treatment protocols and provide high-grade evidence-based medical support for HFNC oxygen therapy in treating acute respiratory failure in COPD.]]> 2025/3/1 0:00:00 QIN Zhiqiang, PAN Yanru 2true ［Abstract］　Chronic obstructive pulmonary disease(COPD) is a common, preventable and treatable chronic respiratory disease. COPD is considered a moderate risk factor for pulmonary embolism(PE). Because the clinical symptoms of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) are similar to those of PE, PE is often delayed in diagnosis and treatment, and the prognosis of the AECOPD complicated with PE patients is severely affected.At present, the pathogenesis of AECOPD complicated with PE is still unclear, and the diagnosis and treatment strategies need to be further improved. In this paper, the latest progress in the study of AECOPD complicated with PE is reviewed.]]> 2025/3/1 0:00:00 1,2, YANG Ruohan¹, LIU Shiqiong³, LIN Huo^1,4, WU Yijing¹, LAI Xingyue¹, DENG Chaosheng¹]]> LUO Zhen^1,2, YANG Ruohan¹, LIU Shiqiong³, LIN Huo^1,4, WU Yijing¹, LAI Xingyue¹, DENG Chaosheng¹ 1true