［Abstract］　Objective　To study the effects of allergic enteritis on the risk of functional gastrointestinal disorders(FGIDs) in infants and young children. Methods　A total of 80 pediatric patients who were diagnosed with allergic enteritis in Changsha Hospital for Maternal and Child Health Care from January 2019 to December 2019 were included as allergic enteritis group, and 80 subjects who were brothers and sisters of the pediatric patients in the allergic enteritis group under 4 years old without a history of milk allergy or were treated in Changsha Hospital for Maternal and Child Health Care due to minor trauma during the same period were included as the control group. The parents of the subjects in the allergic enteritis group and the control group were followed up by telephone every 12 months until the subjects reached the age of 4 years. The immunoglobulin E(IgE) antibody titers of common foods(milk, soybean, rice, wheat and egg) and fecal calprotectin level were detected in all the pediatric patients with allergic enteritis within 1 week before endoscopy by using enzyme-linked immunosorbent assay. The results of endoscopy and pathological examination were recorded. Results　Among the 80 pediatric patients with allergic enteritis, 12 pediatric patients(15.00%) had FGIDs, while only 4 subjects(5.00%) in the 80 subjects of the control group had FGIDs(χ²=2.108, P=0.035). After adjusting for age and gender, multivariate logistic regression analysis showed that the odds ratio(OR)(95%CI) of FGIDs in the allergic enteritis group was 4.39(1.03-18.68). FGIDs were significantly correlated with iron deficiency anemia, duration of hematochezia and age of onset of allergic enteritis(P<0.05). Multivariate logistic regression analysis showed that longer duration of hematochezia was an independent risk factor for the occurrence of FGIDs［OR(95%CI)=3.14(1.72-5.74)］. Conclusion　Allergic enteritis is a risk factor for the development of FGIDs in infants and young children. Longer duration of hematochezia is an independent risk factor for the occurrence of FGIDs.]]> 2025/3/28 0:00:00 LI Jun, XU Jizhi, HUANG Tengfei, CHEN Lingling, HUANG Yan, GONG Xiaohui 4true ［Abstract］　Objective　To explore the effects of short-term intervention of hypoallergenic formulas(HFs) on the relief of clinical symptoms, immune tolerance, growth and development in breastfed infants with food protein-induced allergic proctocolitis(FPIAP). Methods　A total of 67 infants aged 29 days to 6 months who were diagnosed with FPIAP and were mainly breast-fed at Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University from January 1, 2021 to August 31, 2022 were selected. According to dietary restrictions, these infants were divided into hypoallergenic formula group［Breastfeeding was suspended and after 2 weeks of replacing breast milk with amino acid formula(AAF) or extensively hydrolyzed formula, breastfeeding was gradually resumed, 43 cases］ and breastfeeding group(Breastfeeding was continued with maternal food-avoidance diets, 24 cases). The clinical symptom remission after 1 month and 3 months of the feeding, the rates of allergy to complementary foods at the age of 6 to 8 months, and immune tolerance, growth and development at the age of 12 months were compared between the two groups. Results　The rates of clinical symptom remission after interventions for 1 month and 3 months in the hypoallergenic formula group were significantly higher than those in the breastfeeding group(90.70% vs 50.00%, 97.67% vs 62.50%, P<0.05). There were no significant differences in the rates of allergy to complementary foods between the two groups(P>0.05). At the age of 12 months, the proportion of infants acquiring immune tolerance in the hypoallergenic formula group was significantly higher than that in the breastfeeding group(57.58% vs 20.00%, P<0.05). There were no significant differences in body weight, body length, head circumference and their growth between the two groups(P>0.05). Conclusion　The short-term intervention of HFs can promote symptom relief without affecting the resumption of breastfeeding and without affecting long-term growth and development in infants and is beneficial for immune tolerance. Whether to use this method can be determined by the severity of symptoms, the caregiver′s anxiety level and other factors.]]> 2025/3/28 0:00:00 ZHANG Jiyong, ZENG Yongmei, HE Haobing, LI Weiyan, QIU Xiaoying, WANG Yuanyuan, CHEN Youyan, ZENG Fanfei 3true ［Abstract］　Objective　To summarize the clinical features, related gene mutations and genetic status of 14 pediatric patients with sodium taurocholate cotransporting polypeptide(NTCP) deficiency disease and to improve clinicians′ understanding of NTCP deficiency disease in children. Methods　The clinical manifestations, laboratory tests and gene analysis results in the pediatric patients who underwent gene analysis and were diagnosed with NTCP deficiency disease in the People′s Hospital of Guangxi Zhuang Autonomous Region from October 2021 to October 2024 were collected for descriptive statistical analysis. Results　A total of 14 pediatric patients were diagnosed with NTCP deficiency disease, with the initial symptom of jaundice manifesting through yellow skin in 4 cases, elevated total bile acids found during physical examination/hospitalization in 10 cases, and liver enlargement found during physical examination in 3 cases. All the pediatric patients were detected to have SLC10A1 gene variants(c.800C>T, p.Ser267Phe)(chr14:70245193, NM_003049). All the pediatric patients had homozygous variants, and 4 pediatric patients were complicated with other genetic defects, among whom 1 patient was complicated with BLVRA gene heterozygous variants(c.119T>C), 1 patient with HBA2 gene heterozygous variants(c.427T>C), 1 patient with G6PD gene hemizygote variants(c.95A>G), and 1 patient with G6PD gene hemizygote variants(c.1376G>T). Conclusion　All the 14 pediatric patients with NTCP deficiency disease show an increase in total bile acids and are detected to have homozygous variants in SLC10A1. For the pediatric patients with persistent elevation of total bile acids, genetic testing should be perfected as much as possible to definite diagnosis and treatment as early as possible, thereby improving the pediatric patients′ quality of life and prognosis.]]> 2025/3/28 0:00:00 HUANG Fangli, DENG Yinye, LAI Wuchao, WU Dan, TAN Wenhai, MO Haipu, DAI Yan 2true ［Abstract］　Objective　To compare the clinical features between benign convulsions with mild gastroenteritis(CwG) and febrile seizure with gastroenteritis(FSwG) in pediatric patients, and to provide the basis for early assessment and management of CwG. Methods　The clinical data of 99 pediatric patients aged 1-72 months who were hospitalized in Department of Pediatrics, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University for acute gastroenteritis or convulsion with diarrhea from January 2018 to December 2021 were retrospectively collected. According to the body temperature before and after convulsion, the pediatric patients were divided into CwG group(no fever or body temperature <38 ℃, 67 cases) and FSwG group(body temperature ≥38 ℃, 32 cases). The clinical data and outcomes were compared between the two groups. Results　There were no significant differences in age and gender composition between the two groups, but the onset time of the CwG group was more concentrated in the age of >12-24 months. CwG tended to occur in autumn and winter, while FSwG tended to occur in winter and spring. The proportion of seizure clusters in the CwG group was significantly higher than that in the FSwG group(46.27% vs 6.25%, P<0.05). The seizures in the CwG group were more likely to occur at >24-48 hours after gastroenteritis symptoms, and the occurrence of seizures in the CwG group was significantly later than that in the FSwG group［(1.94±0.92)d vs (1.34±0.74)d, P<0.05］. The levels of C-reactive protein(CRP), procalcitonin(PCT), prealbumin(PAB) and HCO^-₃ in the CwG group were lower than those in the FSwG group, while the levels of alanine aminotransferase(ALT), uric acid(UA) and creatine kinase isoenzyme MB(CK-MB) in the CwG group were higher than those in the FSwG group, with statistically significant differences between the two groups(P<0.05). There were no obvious abnormalities in the pediatric patients′ acute stage electroencephalogram(EEG) and skull imaging examination in the two groups. After follow-up of 18 months to 5 years, 12 cases in the CwG group were lost, and 1 case of the other 55 cases had the recurrence of gastroenteritis without febrile seizures. In the FSwG group, 4 cases were lost to follow-up, and 5 cases of the other 28 cases had the recurrence of febrile seizures. Conclusion　CwG is a benign disease that tends to occur in pediatric patients aged 1 to 2 years and is common in autumn and winter, with a tendency to seizure clusters, generally with good prognosis and rarely relapses. When the likelihood of CwG is considered to be high clinically, cerebrospinal fluid examination, skull imaging examination and anticonvulsant therapy may not be necessary even in the acute phase of seizure clusters.]]> 2025/3/28 8:07:34 QIU Xiaoying, ZENG Yongmei, ZHANG Jiyong, XIAO Fei, HAO Jindou, LI Weiyan, WANG Yuanyuan, CHEN Youyan, ZENG Fanfei, DONG Guoqing 1true