［Abstract］　Recurrent hepatocellular carcinoma(rHCC) is a major obstacle affecting the long-term survival of primary hepatocellular carcinoma(HCC) patients after receiving initial treatment for HCC, and their recurrence rate of HCC reaches as high as 70% within 5 years. This paper systematically reviews the latest progress in the field of local and systemic therapies for rHCC. Local therapies include repeat hepatectomy, salvage liver transplantation, radiofrequency ablation, microwave ablation, transarterial chemoembolization, hepatic arterial infusion chemotherapy, transarterial radioembolization as well as newly-developing therapies(such as stereotactic body radiotherapy and proton beam therapy). Systemic therapies include targeted therapy and immunotherapy. These therapies significantly improve the prognosis of patients with rHCC.]]> 2025/9/30 10:04:06 HU Ding, HUANG Jiwei, WANG Haichuan 7true ［Abstract］　Objective　To explore the efficacy between laparoscopic and laparotomic intention-to-cure radical resections for gallbladder cancer, and to provide evidence-based basis for clinical treatment options. Methods　A retrospective analysis was conducted on the clinical data of 150 patients who were admitted to the Second Affiliated Hospital of Kunming Medical University and received intention-to-cure radical resection for gallbladder cancer from January 2017 to December 2022. According to the surgical methods, the patients were divided into laparoscopic surgery group(48 patients) and laparotomic surgery group(102 patients). Propensity score matching(PSM) was used to balance the differences in baseline data. A total of 72 patients were successfully matched, including 36 patients in the laparoscopic surgery group and 36 patients in the laparotomic surgery group. The differences in perioperative indicators and survival prognosis were compared between the two groups. The risk factors affecting the survival prognosis of the patients were analyzed by using Cox regression. Results　After matching, the baseline data in the two groups were balanced. The laparoscopic surgery group had significantly less intraoperative blood loss and significantly shorter postoperative hospital stay than the laparotomic surgery group(P<0.05). The results of survival analysis showed that for the gallbladder cancer patients with stage T₃ and below, there was no significant difference in overall survival between the laparoscopic surgery group and the laparotomic surgery group(P>0.05). The results of Cox regression analysis showed that complicating cholecystolithiasis and stage T₃ were independent risk factors affecting the GBC patients′ survival prognosis［HR(95%CI)=1.70(1.02-2.83), P=0.040; HR(95%CI)=6.07(1.44-25.60), P=0.014］. Conclusion　In radical cholecystectomy, for the patients with stage T₃ and below who have been strictly screened, the efficacy of laparoscopic surgery is comparable to that of laparotomic surgery. However, the conclusion still requires more high-quality evidence-based practice for further verification.]]> 2025/9/30 10:04:06 ZHENG Kai, JIANG Gaiming, LI Jing, KANG Qiang, YANG Chen, KE Yang, LI Yuehua 6true ［Abstract］　Objective　To explore the value of preoperative albumin-bilirubin(ALBI) grade in predicting patients′ clinical prognosis after radical resection of hilar cholangiocarcinoma(HCCA). Methods　The clinical data of 115 patients with HCCA who underwent surgical treatment in the Second Affiliated Hospital of Kunming Medical University from July 2015 to December 2022 were retrospectively analyzed. The ALBI was calculated based on the albumin and bilirubin values of the HCCA patients within 1 week before the operation. According to the ALBI grading system(ALBI≤-2.60 as grade 1, -2.60-1.39 as grade 3), the HCCA patients were graded, including 4 patients with ALBI grade 1, 91 patients with ALBI grade 2 and 20 patients with ALBI grade 3. The survival prognosis of the HCCA patients in the preoperative ALBI grade 1-2 group(Due to the small number of patients with ALBI grade 1, the patients with ALBI grade 1 and those with ALBI grade 2 were combined into one group) and the preoperative ALBI grade 3 group was compared. The factors affecting the survival prognosis of the patients were analyzed by using Cox regression. Results　The median disease-free survival(DFS) of the patients in the preoperative ALBI grade 1-2 group and the preoperative ALBI grade 3 group was 23 months and 10 months, respectively, with statistically significant difference in prognosis of DFS between the two groups(P<0.05), and their median overall survival(OS) was 36 months and 17 months, respectively, with statistically significant difference in prognosis of OS between the two groups(P<0.05). The results of multivariate Cox regression analysis showed that preoperative ALBI grade 3, vascular carcinoma embolus and American Joint Committee on Cancer(AJCC) stages(TNM stages) Ⅲ and Ⅳ were independent risk factors for DFS in the HCCA patients after operation(P<0.05), and preoperative ALBI grade 3, AJCC stages(TNM stages) Ⅲ and Ⅳ were independent risk factors for OS in the HCCA patients after operation(P<0.05). Conclusion　Preoperative ALBI grade has predictive value for the prognosis of HCCA patients after radical resection of HCCA.]]> 2025/9/30 10:04:06 QIAN Chunhang, GENG Qin, KANG Qiang, LI Jing, YANG Chen, KE Yang, LI Yuehua 5true ［Abstract］　Objective　To construct a health education program for integrated traditional Chinese medicine and Western medicine(TCM-WM) nutritional support for colon cancer patients based on Patient-Generated Subjective Global Assessment(PG-SGA). Methods　After literature research and group discussion, the initial draft of the health education program for TCM-WM nutritional support based on PG-SGA was constructed. After consulting 14 experts by letter using the Delphi technique, the items of the program were modified and added or deleted to determine the final program. Results　The effective response rates of the expert inquiry questionnaires in the first round and the second round of the consultation were 100.00% and 93.33%, respectively. The expert reliability coefficient(Cr) was 0.765 in the first round of the consultation, and 0.766 in the second round of the consultation, and the Kendall′s W coefficients were 0.184 and 0.164, respectively(all P values <0.01). The health education program of TCM-WM nutritional support for colon cancer patients based on PG-SGA was consisted of 6 first-level items, 19 second-level items and 57 third-level items. Its contents covered nutrition risk assessment, education team, nutritional support program of Western medicine and nutritional support program of traditional Chinese medicine, health education approaches and effect evaluation. Conclusion　The health education program provides a systematic and standardized practical reference for the nutritional support and health education of the patients with colon cancer, which has positive significance for improving the patients′ nutritional status, quality of life and treatment compliance.]]> 2025/9/30 10:04:06 1, LI Zhi², SUN Shanghui², CHE Yizhan², QIU Xiaoqiao², OU Yixuan², DONG Lijuan³]]> XIE Qing¹, LI Zhi², SUN Shanghui², CHE Yizhan², QIU Xiaoqiao², OU Yixuan², DONG Lijuan³ 4true ［Abstract］　Objective　To investigate the differences in the imaging features of cone-beam breast computed tomography(CBBCT) between central intraductal papilloma(IDP) and peripheral IDP, and to evaluate the application value of CBBCT in preoperative differential diagnosis. Methods　A retrospective analysis was conducted on the clinical and imaging data of 96 patients who underwent CBBCT in Guangxi Medical University Cancer Hospital from July 2019 to December 2023 and whose surgical specimens were pathologically confirmed as IDP. Among these patients, there were 57 patients in central IDP group and 39 patients in peripheral IDP group. The CBBCT imaging features and related measurement indicators of the lesions were analyzed and compared between the two groups. Results　Compared with the peripheral IDP group, the central IDP group had shorter distance from the anterior edge of the lesion to the base of the nipple［(1.12±1.03)cm vs (3.83±1.87)cm, P<0.05］, and higher proportion of the long axis of the lesions following the same course as the mammary duct(84.21% vs 51.28%, P<0.05), and higher standardized CT values of each stage in plain CT scan and enhanced CT scan(P<0.05). There were no significant differences in the maximum diameter of the lesions, enhancement types, duct dilatation, vascular signs around the lesions, precontrast CT density, enhancement rate and time-density curve(TDC) types between the two groups(P>0.05). Both groups were mainly characterized by smooth edges, round or oval shapes, and uniformly enhanced mass-like enhancement of the lesions, while TDC was mainly platform-like. Conclusion　There are certain differences in CBBCT imaging features between central IDP and peripheral IDP, especially in the location of the lesion(distance from the base of the nipple), morphology of the lesion(the long axis following the same course as the mammary duct) and enhanced degree(standardized CT values). These features are helpful for the preoperative classification and diagnosis of IDP.]]> 2025/9/30 10:04:06 FENG Xianmei, ZHAO Xin, WEI Wei, HUANG Lei, ZHENG Zhongtao 3true ［Abstract］　Objective　To explore the clinical efficacy of steam medicine cupping therapy in opioid-induced constipation(OIC) in patients with cancer pain. Methods　Seventy cancer pain patients with OIC who were hospitalized in Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine from October 2024 to April 2025 were recruited. The patients were divided into control group and observation group by random number table method, with 35 patients in each group. During the treatment process, 1 patient dropped out in the control group, and 34 patients were eventually included. During the treatment process, 2 patients dropped out in the observation group, and 33 patients were eventually included. The control group received routine nursing care, while the observation group received routine nursing care plus steam medicine cupping therapy. The number of complete spontaneous bowel movements(CSBMs) per week, Bristol Stool Form Scale(BSFS) scores, the frequency of bowel sounds, Patient Assessment of Constipation Symptoms(PAC-SYM) questionnaire scores, Patient Assessment of Constipation Quality of Life(PAC-QoL) questionnaire scores, Self-Rating Anxiety Scale(SAS) scores, and Self-Rating Depression Scale(SDS) scores were compared between the two groups to evaluate their clinical efficacy. Results　After 1 course of intervention, the CSBMs and BSFS scores in both groups were higher than those before intervention, and CSBMs and BSFS scores in the observation group were higher than those in the control group after 1 course of intervention, with statistically significant differences(P<0.05). The scores of PAC-SYM questionnaire, PAC-QoL questionnaire, SAS and SDS in both groups after 1 course of intervention were lower than those before intervention, and the scores of PAC-SYM questionnaire, PAC-QoL questionnaire, SAS and SDS in the observation group were lower than those in the control group after 1 course of intervention, with statistically significant differences(P<0.05). After each intervention, there was statistically significant difference in the frequency of bowel sounds between the two groups(P<0.05). No obvious adverse reactions occurred during the therapeutic process. Conclusion　Steam medicine cupping therapy can significantly improve OIC and its accompanying symptoms in patients with cancer pain and enhances their quality of life.]]> 2025/9/30 10:04:06 ZHANG Yuxuan, WU Wenxin, SANG Guanglin, DONG Fangping, LI Jiuli, CHEN Huibing 2true ［Abstract］　Objective　To explore the effects of remimazolam combined with nerve block on intraoperative hemodynamics and postoperative cognitive function in elderly patients undergoing laparoscopic surgery for colorectal malignant tumors under general anesthesia. Methods　A total of 120 elderly patients undergoing elective laparoscopic surgery for colorectal malignant tumors in the People′s Hospital of Guangxi Zhuang Autonomous Region from June 2023 to December 2024 were recruited. The patients were divided into four groups by using random number table method: simple general anesthesia group(group G), general anesthesia combined with nerve block group(group N), general anesthesia combined with remimazolam group(group R), and general anesthesia combined with remimazolam and nerve block group(group RN). In group R and group RN, remimazolam was continuously pumped 10 minutes before anesthesia induction until the end of the operation. In group N and group RN, bilateral rectus sheath block and transversus abdominis plane block were performed after anesthesia induction. All the patients in the four groups received the same anesthesia induction and maintenance regimens. The mean arterial pressure(MAP) and heart rate(HR) were recorded 10 minutes before anesthesia induction(T₀), during tracheal intubation(T₁), 5 minutes after tracheal intubation(T₂), 1 hour after the start of the operation(T₃), and at the end of the operation(T₄). The changing values of MAP and HR at each time point compared to those at T₀ were calculated and were denoted as ΔMAP and ΔHR, respectively. The Mini-Mental State Examination(MMSE) scores of the patients were compared at 1 day before the operation, 3 days after the operation, and 7 days after the operation. The incidence rates of postoperative cognitive dysfunction(POCD) and adverse reactions of the patients were recorded. Results　The ΔMAP and ΔHR in group RN and group R were lower than those in group G and group N at the time points of T₁ and T₂(P<0.05). The ΔMAP and ΔHR in group RN were lower than those in group R, group N and group G at the time points of T₃ and T₄(P<0.05). The MMSE scores of the patients in group R and group RN were higher than those in group G and group N at 3 days and 7 days after the operation(P<0.05). There was no statistically significant difference in the incidence of POCD of the patients among the four groups(P>0.05). There was no statistical difference in the incidence of adverse reactions of the patients among the four groups(P>0.05). Conclusion　In laparoscopic surgery for the elderly patients with colorectal malignant tumors under general anesthesia, the application of remimazolam combined with nerve block on the basis of conventional anesthesia is beneficial for maintaining the patients′ intraoperative hemodynamic stability, improving their postoperative cognitive function, and does not increase the incidence of adverse reactions, thus exhibiting high safety.]]> 2025/9/30 10:04:06 ZHANG Yu, WANG Yonghao, ZHONG Yuling, FANG Haiyan, JIANG Qiuxiang, QU Hanqing, DAI Luming, GONG Zheng 1true