2026/9/30 9:59:14 2026/9/30 9:59:17 Chinese Journal of New Clinical Medicine]]> ［Abstract］　Polycystic ovary syndrome(PCOS) is commonly associated with metabolic abnormalities, which increases the risks of ovulation disorder, infertility, spontaneous abortion, pregnancy complications, and adverse offspring health outcomes. To improve pregnancy outcomes and offspring health in women with PCOS, pre-conception health management is of paramount importance. However, no standardized clinical guidelines currently exist for pre-conception management targeting this specific population. This consensus summarizes the epidemiology of metabolic abnormalities in PCOS, their impact on reproductive health, diagnostic criteria, and key aspects of pre-conception management. Based on clinical evidence and the experience of multidisciplinary experts, it proposes control targets for correcting metabolic abnormalities, introduces the pregnancy safety categories and usage recommendations for commonly used medications, and emphasizes that certain drugs are prescribed off-label, for which full disclosure and informed consent should be obtained from the patients before using these medications.]]> 2026/9/30 9:59:14 ［Abstract］　Adenomyosis is a benign gynecological condition characterized by the invasion of endometrial glands and stroma into the myometrium. It is closely associated with abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, infertility, and adverse pregnancy outcomes, significantly impairing the patients′ quality of life. Transvaginal ultrasound(TVUS), owing to its convenience, cost-effectiveness, and capacity for dynamic observation, has become the first-line imaging modality for diagnosing adenomyosis. With the continuous advancement of ultrasound imaging and image processing technologies—including three-dimensional(3D) ultrasound, contrast-enhanced ultrasound and elastography—as well as the establishment of the standardized diagnostic system for Morphological Uterus Sonographic Assessment(MUSA), the diagnostic accuracy of ultrasound for adenomyosis has been substantially improved. Furthermore, its application is progressively expanding into disease typing, severity grading, and therapeutic efficacy monitoring. This review summarizes the latest research progress in the ultrasound diagnosis of adenomyosis.]]> 2026/9/30 9:59:14 1, Liu Jie¹, Li Xiaodong²]]> ［Abstract］　Adenomyosis is a common benign disease in women of reproductive age, characterized pathologically by the infiltration of endometrial glands and stroma into the myometrium. For patients with fertility aspirations, the therapeutic paradigm has shifted from solely pursuing complete lesion excision to a comprehensive approach that balances lesion burden control, preservation of uterine structural integrity, and improvement of pregnancy outcomes. This review systematically summarizes current advancements in the diagnostic assessment of adenomyosis, fertility-sparing surgical techniques, and minimally invasive interventional therapies, including high-intensity focused ultrasound(HIFU), uterine artery embolization(UAE), and radiofrequency ablation(RFA), with a focus on their efficacy and safety. Special emphasis is placed on factors influencing reproductive outcomes and strategies for patient selection. Formulating individualized strategies based on disease type, patient characteristics, and fertility goals, together with standardized perioperative management and consideration of obstetric risks such as uterine rupture and placenta accreta spectrum disorders, is crucial for improving pregnancy outcomes.]]> 2026/9/30 9:59:14 1, Liang Zhiqing²]]> ［Abstract］　Adenomyosis is a common benign gynecological disease that can lead to dysmenorrhea, menorrhagia, chronic pelvic pain, and infertility. Although traditional hysterectomy provides definitive symptom relief, it fails to meet the treatment needs of young patients and those with a desire to preserve the uterus or maintain fertility.In recent years, thermal ablation technologies such as high-intensity focused ultrasound(HIFU), radiofrequency ablation(RFA), and microwave ablation(MWA) have gradually been applied to the treatment of adenomyosis, providing new options for uterus-sparing therapy. Existing studies indicate that image-guided thermal ablation can effectively alleviate dysmenorrhea and menorrhagia, reduce lesion size and uterine volume, and achieve favorable reproductive outcomes in some patients. However, adenomyotic lesions lack clear boundaries and exhibit an infiltrative interdigitation with normal myometrium. Therefore, treatment of adenomyosis requires not only a focus on symptom improvement but also the protection of vital structures, consideration of fertility needs, and long-term disease management. This review summarizes the characteristics of thermal ablation technologies, clinical decision-making, symptom control, fertility preservation, combination therapies, and safety, aiming to provide a reference for clinical practice in the thermal ablation treatment of adenomyosis.]]> 2026/9/30 9:59:15 1, Feng Xiao², Gong Xiaoming¹]]> ［Abstract］　Adenomyosis(AM) is a common benign uterine disorder in childbearing age women. It is characterized by typical clinical manifestations such as dysmenorrhea, menorrhagia, and compressive symptoms caused by uterine enlargement, with significant negative impacts on female fertility. Due to the infiltrative growth patterns of adenomyosis lesions, adenomyosis poses a persistent therapeutic challenge. Both pharmacological and conventional surgical treatments have inherent limitations. Exploring treatment modalities with fewer adverse reactions and less invasiveness has always been a clinical hotspot. Focused ultrasound ablation surgery(FUAS), also known as high-intensity focused ultrasound(HIFU) ablation, is a non-invasive therapeutic technique that has emerged in recent years. Extensive studies have confirmed its safety and efficacy. At present, it has become an important means for clinicians to treat adenomyosis and has been included in Chinese expert consensus guidelines. This review summarizes the current status and research progress of FUAS in the treatment of adenomyosis.]]> 2026/9/30 9:59:15 1, Zhang Lian²]]> ［Abstract］　Adenomyosis is a common benign uterine disease in women of reproductive age, characterized by progressively aggravated dysmenorrhea, menorrhagia, chronic pelvic pain and infertility, which seriously affects the quality of life and reproductive outcomes of patients. The etiology of adenomyosis is complex and its pathogenesis remains incompletely elucidated. Although hysterectomy remains the radical cure for adenomyosis, drug therapy plays an irreplaceable role in fertility preservation, recurrence prevention and long-term management. In recent years, significant progress has been made in drug therapies for adenomyosis. High-level evidence has accumulated regarding the efficacy, safety, and long-term management of progestogens, gonadotropin-releasing hormone(GnRH) agonists and antagonists, and selective progesterone receptor modulators(SPRMs). Furthermore, combination regimens have further optimized the balance between therapeutic efficacy and tolerability. The discovery of new targets, including prolactin receptors, and the development of targeted monoclonal antibody drugs offer new hope for refractory cases. This review summarizes the efficacy and safety of commonly used therapeutic drugs, advances in novel drug research, the development of new targets, and future research directions for adenomyosis, aiming to provide a reference for rational drug therapy and subsequent studies.]]> 2026/9/30 0:00:00 ［Abstract］　Adenomyosis is a common benign gynecological condition that severely affects the quality of life in women of reproductive age. The levonorgestrel-releasing intrauterine system(LNG-IUS) is recommended by clinical guidelines as the first-line conservative treatment for adenomyosis due to its ease of insertion and effectiveness in alleviating dysmenorrhea and reducing menstrual blood loss. However, patients with adenomyosis often present with an enlarged uterine volume, distorted uterine cavity morphology, and abnormally enhanced myometrial contractility, which significantly increase the rate of LNG-IUS expulsion after its conventional insertion. According to reports, the spontaneous expulsion rates of LNG-IUS in adenomyosis patients within one year of its insertion range from 10% to 25%. To address this challenge, various intrauterine fixation techniques for LNG-IUS have been explored in clinical practice. This paper summarizes the main methods of intrauterine LNG-IUS fixations for patients with adenomyosis, including suture fixation, the GyneFix-assisted Mirena combination ring fixation and non-suture fixation. It focuses on summarizing the specific procedures, technical advantages, limitations, and challenges associated with each technique, aiming to provide reference for clinicians in selecting appropriate fixation strategies.]]> 2026/9/30 9:59:15 ［Abstract］　Objective　To investigate the clinical efficacy and application value of ultrashort wave combined with blood flow restriction resistance training(BFR-RT) in relieving pain, improving joint function and balance ability, and reducing inflammatory levels in patients with knee osteoarthritis(KOA). Methods　A total of 92 patients with Kellgren-Lawrence grade Ⅱ-Ⅲ KOA who were admitted to the First Medical Centre of Chinese PLA General Hospital from February 2024 to December 2024 were enrolled as study subjects. The patients were divided into observation group and control group by random number table method, with 46 patients in each group. The control group received conventional rehabilitation training, while the observation group received ultrashort wave combined with BFR-RT at 30% one-repetition maximum(1RM). The intervention period was 8 weeks for both groups. Visual Analogue Scale(VAS) scores, Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) scores and Berg Balance Scale(BBS) scores were compared between the two groups before intervention, 4 weeks after intervention, and 8 weeks after intervention. Serum levels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were measured before intervention and at 8 weeks post-intervention. Results　After intervention, the VAS scores and WOMAC scores in both groups showed a downward trend(P<0.05). Moreover, the VAS scores and WOMAC scores in the observation group were lower than those in the control group 4 weeks and 8 weeks after intervention, with statistically significant differences(P<0.05). After intervention, the BBS scores in both groups showed an upward trend(P<0.05), and the BBS scores in the observation group were higher than those in the control group 4 weeks and 8 weeks after intervention, with statistically significant differences(P<0.05). At 8 weeks post-intervention, the levels of IL-6 and TNF-α in both groups were lower than those before intervention, and the IL-6 and TNF-α levels in the observation group were lower than those in the control group after intervention, with statistically significant differences(P<0.05). During the intervention period, no severe adverse events occurred in either group. Conclusion　Ultrashort wave combined with BFR-RT is safe and effective in rapidly relieving pain, reducing local inflammation, significantly improving joint function and balance ability in KOA patients. The combination can provide an optimized therapeutic regime for non-surgical treatment of Kellgren-Lawrence grade Ⅱ-Ⅲ KOA.]]> 2026/9/30 9:59:15 1,Wang Gang²,Tian Yuling³]]> ［Abstract］　Objective　To analyze effects of gestational diabetes mellitus(GDM) on early-onset infection in full-term newborns with high-risk factors for perinatal infection, thereby providing a basis for the timely identification of potential infection risks and effective perinatal interventions. Methods　A retrospective analysis was conducted on the clinical data of 578 full-term newborns delivered in Department of Obstetrics, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University between October 2020 and December 2022, who possessed high-risk factors for perinatal infection. The newborns were divided into infection group(n=159) and non-infection group(n=419) according to whether early-onset infection occurred, and their mothers were classified into GDM group(n=112) and non-GDM group(n=466) according to whether they had maternal GDM. All the mothers in the GDM group maintained blood glucose levels within the normal range through diet and exercise intervention. Multivariate logistic regression analysis was employed to identify risk factors for early-onset infection in the newborns. Results　No statistically significant difference was observed in the incidence of early-onset infection between the GDM group and the non-GDM group(30.36% vs 26.82%, χ²=0.565, P=0.452). The proportion of male infants, birth weight, and gestational age in the infection group were significantly larger than those in the non-infection group(P<0.05). The proportions of cesarean section, intrapartum fever, grade Ⅲ meconium-stained amniotic fluid(MSAF) and elevated pre-partum serum inflammatory markers in the mothers of the infection group were significantly higher than those in the mothers of the non-infection group(P<0.05), while the proportion of positive group B Streptococcus(GBS) culture from maternal cervical secretions at the end of pregnancy in the infection group was significantly lower than that in the non-infection group(P<0.05). Multivariate logistic regression analysis revealed that increased gestational age, maternal intrapartum fever, and elevated pre-partum serum inflammatory markers were independent risk factors for early-onset infection in the newborns(P<0.05), whereas maternal GDM showed no independent correlation with early-onset infection in the newborns(P>0.05). In the infection group, procalcitonin(PCT) levels in infants of GDM mothers were significantly lower than those in infants of non-GDM mothers 3 days after treatment［0.25(0.16, 0.38)ng/mL vs 0.35(0.24, 0.58)ng/mL, Z=2.354, P=0.019］; no statistically significant differences were found in the other data between the two groups(P>0.05). Conclusion　For full-term newborns with high-risk factors for perinatal infection, maternal GDM controlled by diet and exercise intervention to maintain normal blood glucose levels does not increase the risk of early-onset infection in the full-term newborns, nor does it exacerbate the severity of existing infections or prolong hospital stay. Increased gestational age, maternal intrapartum fever and elevated pre-partum serum inflammatory markers are independent risk factors for early-onset infection in newborns.]]> 2026/9/30 9:59:15 1, Sun Rui¹, Chao Shuang¹, Zhang Lei², Huang Zhenyu², Wang Yuejiao¹]]> ［Abstract］　Objective　To investigate the effect of intensive lipid-lowering with the proprotein convertase subtilisin/kexin type 9(PCSK9) inhibitor evolocumab on alleviating symptomatic intracranial atherosclerotic stenosis(sICAS). Methods　The clinical data of 56 patients with sICAS who were admitted to Department of Neurology, People′s Hospital of Hunan Province and received evolocumab combined with statin therapy(observation group) from January 1, 2022 to June 1, 2024 were retrospectively collected. After matching for sex, age, height, body mass, smoking history, hypertension, diabetes mellitus, coronary heart disease, use of antiplatelet agents, history of stroke, and National Institutes of Health Stroke Scale(NIHSS) scores, the clinical data of 56 patients with sICAS who received statin monotherapy(control group) at the same peroid were collected. Both groups were treated for 6 months. The intracranial arterial stenosis rate, lipid profile, blood routine parameters, and blood biochemical indicators were compared between the two groups before and after treatment. Logistic regression analysis was used to identify factors affecting changes in the degree of intracranial arterial stenosis and the achievement of target low-density lipoprotein cholesterol(LDL-C) levels after treatment. Results　After treatment, the stenosis rate of the middle cerebral artery significantly decreased in both groups(P<0.05). In the observation group, the stenosis rates of the internal carotid artery(segments C5 and C6), anterior cerebral artery, vertebral artery, basilar artery, and posterior cerebral artery after treatment were significantly lower than those before treatment(P<0.05), while no significant changes were observed in the control group(P>0.05). After treatment, the internal carotid artery(segments C5 and C6) stenosis rate in the observation group was significantly lower than that in the control group(P<0.05); however, differences in stenosis rates of other intracranial arteries between the two groups were not statistically significant(P>0.05). After treatment, total cholesterol(TC) and LDL-C levels decreased compared with those before treatment in both groups, and the levels in the observation group were lower than those in the control group after treatment, with statistically significant differences(P<0.05). The LDL-C target achievement rate in the observation group was significantly higher than that in the control group(69.64% vs 25.00%; χ²=22.386,P<0.001). Multivariate logistic regression analysis revealed that use of evolocumab was an independent protective factor for promoting the reduction of stenosis degree of intracranial arteries(P<0.05), while higher LDL-C level was an independent risk factor for inhibiting the reduction of stenosis degree(P<0.05). Use of evolocumab was also an independent protective factor for promoting LDL-C target achievement after treatment(P<0.05), whereas older age was an independent risk factor for inhibiting LDL-C target achievement after treatment(P<0.05). Conclusion　For patients with sICAS, the addition of the PCSK9 inhibitor evolocumab to statin therapy can more effectively reduce LDL-C levels and contribute to alleviating the degree of intracranial arterial stenosis.]]> 2026/9/30 9:59:15 ［Abstract］　Objective　To analyze the associations of Zhejiang University(ZJU) index and pan-immune-inflammation value(PIV) with insulin resistance(IR) and neonatal outcomes in pregnant women with gestational diabetes mellitus(GDM). Methods　The clinical data were retrospectively collected from 188 pregnant women with GDM(GDM group) who underwent prenatal care and delivery in Yulin Hospital, the First Affiliated Hospital of Xi′an Jiaotong University between January 2023 and February 2025. Additionally, 188 pregnant women with normal glucose tolerance, confirmed by oral glucose tolerance test(OGTT), were enrolled as control group. The participants in the control group were matched 1∶1 with the GDM group based on age, pre-pregnancy body mass index(BMI), and gestational age. The ZJU index, PIV, and homeostasis model assessment of insulin resistance(HOMA-IR) levels were compared between the two groups. Spearman rank correlation analysis was performed to evaluate the correlations of ZJU index and PIV with HOMA-IR in GDM patients. Furthermore, the GDM patients were stratified into a poor neonatal outcome group(n=51) and a favorable neonatal outcome group(n=137) based on neonatal outcomes. Multivariate logistic regression analysis was employed to identify factors affecting neonatal outcomes of the GDM patients. The predictive performance of ZJU index and PIV for poor neonatal outcomes in the GDM patients was assessed using receiver operating characteristic(ROC) curve analysis. Results　The levels of ZJU index, PIV and HOMA-IR in the GDM group were significantly higher than those in the control group(P<0.05). Spearman correlation analysis revealed positive correlations of ZJU index(r_s=0.694, P<0.001) and PIV(r_s=0.617, P<0.001) with HOMA-IR in the GDM patients. Multivariate logistic regression analysis indicated that elevated levels of HOMA-IR［OR(95%CI)=1.407(1.203-1.646)］, ZJU index［OR(95%CI)=1.356(1.203-1.528)］ and PIV［OR(95%CI)=1.107(1.064-1.153)］ were independent risk factors for poor neonatal outcomes in the GDM patients(P<0.05). Both ZJU index and PIV demonstrated effective predictive capabilities for poor neonatal outcomes(P<0.05). Notably, the combined use of the two indicators yielded superior predictive performance compared to either indicator alone(Z_{combination of the two indicators-ZJU index}=3.758, P<0.001; Z_{combination of the two indicators-PIV}=3.418, P=0.001), with a sensitivity of 78.43% and a specificity of 81.02%. Conclusion　Elevated ZJU index and PIV are associated with increased IR and poor neonatal outcomes in pregnant women with GDM. The combined assessment of the two indicators may facilitate risk stratification management for the GDM patients, thereby improving maternal and neonatal prognoses.]]> 2026/9/30 9:59:16 ［Abstract］　Objective　To investigate the gene mutation spectrum of pediatric patients from Guangxi region who failed hearing screening using whole-genome sequencing(WGS). Methods　A total of 64 pediatric patients who were admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region and failed hearing screening from April 2022 to October 2024 were enrolled in this study. Hearing levels were graded using multiple auditory steady-state response(ASSR). WGS was performed on peripheral blood samples collected from the enrolled pediatric patients. Genetic variants were screened and annotated through standard protocols, and their pathogenicity was classified according to the guidelines of the American College of Medical Genetics and Genomics(ACMG). Results　Among the 64 pediatric patients, bilateral profound hearing loss was predominant(54.69%, 35/64). WGS results showed that no pathogenic(P) or likely pathogenic(LP) variants that could explain the phenotypes were identified in 17 pediatric patients(26.56%, 17/64); 29 pediatric patients(45.31%, 29/64) harbored single-gene variants, and 18 pediatric patients(28.13%, 18/64) carried multigenic variants. The detection rate of variants in the GJB2 gene was relatively high(34.38%, 22/64). A total of 18 candidate variant sites that had not been previously reported in databases or the literature were identified, including SLC26A4 c.918+1G>A. Conclusion　The genetic etiology of pediatric patients from Guangxi region who fail hearing screening exhibits significant heterogeneity, providing a supplement to the deafness gene variant spectrum in the region.]]> 2026/9/30 9:59:16 ［Abstract］　Objective　To investigate the clinical efficacy of vancomycin combined with nose ring drainage-assisted transverse tibial bone transport in treating chronic osteomyelitis of the foot and ankle and its impact on inflammatory response. Methods　A total of 148 patients with chronic osteomyelitis of the foot and ankle who were admitted to Handan First Hospital from January 2023 to December 2024 were enrolled and randomly divided into an observation group(n=74) and a control group(n=74) by random number table method. The control group received vancomycin combined with conventional bone transport therapy, while the observation group received vancomycin combined with nose ring drainage-assisted transverse tibial bone transport therapy. The clinical efficacy, inflammatory indicators, degree of pain, therapy-related indicators, clearance rate of methicillin-resistant Staphylococcus aureus(MRSA), postoperative complications, and recurrence rate were compared between the two groups. Results　The excellent and good rates for bone healing and functional recovery in the observation group were significantly higher than those in the control group(98.65% vs 90.54%, χ²=4.757, P=0.029; 97.30% vs 87.84%, χ²=4.812, P=0.028). The levels of white blood cell count(WBC), C-reactive protein(CRP), and interleukin-6(IL-6) in both groups after operation decreased compared with those before operation, and the indicator levels in the observation group were lower than those in the control group after operation, with statistically significant differences(P<0.05). Visual Analogue Scale(VAS) scores decreased postoperatively in both groups; however, the observation group exhibited higher VAS scores than the control group after operation, with statistically significant differences(P<0.05). The duration of vancomycin administration and wound healing time in the observation group were significantly shorter than those in the control group(P<0.05), whereas no significant difference was observed in the duration of bone transport between the two groups(P>0.05). The total MRSA clearance rate in the observation group was significantly higher than that in the control group(P<0.05). During the 6-month follow-up period, the total incidence of complications in the observation group was significantly lower than that in the control group(4.05% vs 13.51%; χ²=4.132, P=0.042), while there was no significant difference in recurrence rate between the two groups(6.76% vs 4.05%; χ²=0.132, P=0.716). Conclusion　Vancomycin combined with nose ring drainage-assisted transverse tibial bone transport can effectively control inflammatory responses, promote rapid rehabilitation, and demonstrate favorable overall clinical outcomes in treatment of chronic osteomyelitis of the foot and ankle.]]> 2026/9/30 9:59:16 ［Abstract］　Objective　To explore the feasibility and short-term clinical efficacy of modified flat mesh in laparoscopic totally extraperitoneal inguinal hernia repair(TEP). Methods　A retrospective analysis was conducted on the clinical data of 116 patients with inguinal hernia who underwent TEP in the Department of Laparoscopic Surgery of Wuxi People′s Hospital Affiliated to Nanjing Medical University from May 2022 to June 2024. All the patients underwent TEP under general anesthesia with the intraoperative placement of an individually trimmed Jiali mesh. This modified flat mesh was designed to conform to the anatomical structure of the retropubic space(space of Retzius). The operative duration, intraoperative blood loss, postoperative complications(such as seroma and chronic pain), and recurrence of hernia were observed and recorded. Results　The operations were successfully performed on the 116 patients, with average operative duration of (33.00±12.00)min and intraoperative blood loss of (20.00±10.00)mL. The patients were followed up for 3 to 24 months after the operation. Among the 116 patients, 9 patients developed seroma and got improvement after conservative treatment and 7 patients developed chronic pain and got improvement after symptomatic treatment. No hernia recurrence was observed. Conclusion　The modified flat mesh is clinically feasible for application in TEP. No recurrence of hernia is observed during the follow-up period, and postoperative complications such as seroma and chronic pain are generally controllable.]]> 2026/9/30 9:59:16 ［Abstract］　Objective　To observe the efficacy of phacoemulsification cataract extraction+intraocular lens(IOL) implantation combined with angle recession surgery in treatment of acute primary angle-closure glaucoma(APACG) complicated by cataract and to analyze its effects on optic nerve structure. Methods　A total of 128 patients with APACG complicated by cataract who were admitted to Tongren People′s Hospital from June 2021 to January 2025 were recruited. The patients were randomly divided into observation group and control group, with 64 patients in each group. The observation group was treated with phacoemulsification cataract extraction+IOL implantation combined with angle recession surgery, while the control group was treated with phacoemulsification cataract extraction+IOL implantation combined with trabeculectomy. The optic nerve fiber thickness, anterior chamber depth, anterior chamber angle and intraocular pressure were compared between the two groups before the operation(T₀), 1 week after the operation(T₁) and 1 month after the operation(T₂). The best corrected visual acuity(BCVA) was compared between the two groups at T₀, T₂, T₃(3 months after the operation) and T₄(6 months after the operation). The incidence of complications and the recurrence of goniosynechia were compared between the two groups. Results　The anterior chamber depth and anterior chamber angle in both groups showed an upward trend postoperatively(P<0.05), while the intraocular pressure showed a downward trend(P<0.05). The anterior chamber depth and anterior chamber angle in the observation group were greater than those in the control group at the time points of T₁ and T₂, while the intraocular pressure in the observation group was lower than that in the control group, with statistically significant differences(P<0.05). The thickness of optic nerve fibers in both groups showed a trend of first decreasing and then increasing after the operation(P<0.05). At the time point of T₁, the optic nerve fiber thickness in the observation group was significantly greater than that in the control group(P<0.05). At the time point of T₂, no statistically significant difference in optic nerve fiber thickness was observed compared with that at the time point of T₀ within the same group(P>0.05), with no statistically significant difference between the two groups at the time point of T₂(P>0.05). The postoperative BCVA in both groups showed an upward trend(P<0.05), and the BCVA in the observation group was higher than that in the control group at the time points of T₂, T₃ and T₄, with statistically significant difference(P<0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant(3.13% vs 14.06%; χ²=4.873, P=0.027). No recurrence of goniosynechia occurred in either group within 6 months postoperatively. Conclusion　Phacoemulsification cataract extraction+IOL implantation combined with angle recession surgery can achieve a relatively satisfactory outcome in the treatment of APACG complicated by cataract. The combined treatment can effectively control intraocular pressure, improve vision, cause minimal damage to the retina, and has good safety.]]> 2026/9/30 9:59:16 ［Abstract］　Objective　To analyze the perinatal high-risk factors for neonatal cow′s milk protein allergy(CMPA) and to provide a basis for early prevention and control of the disease in clinical practice. Methods　The clinical data of 307 neonates with CMPA(CMPA group) who were hospitalized in the Department of Neonatology of Maternity and Child Health Care of Guangxi Zhuang Autonomous Region from January 2023 to April 2025 were retrospectively collected. According to the principle of similar gestational age, 614 neonates were matched at a ratio of 1∶2 as the control group from the non-CMPA neonates who were hospitalized during the same period. The perinatal data of the neonates were collected. Multivariate logistic regression was used to analyze the perinatal influencing factors of neonatal CMPA. Results　There were no statistically significant differences in gender, gestational age, postnatal age at first breastfeeding, and the proportion of mild neonatal pneumonia between the two groups(P>0.05). The birth weight and the proportion of the neonates with hyperbilirubinemia in the CMPA group were lower than those in the control group. The proportion of the neonates with low birth weight, the proportion of the neonates born by cesarean section, the proportion of the neonates having first-degree relatives with a history of allergy and the proportion of the neonates receiving perinatal antibiotic treatment in the CMPA group were higher than those in the control group, with statistically significant differences between the two groups(P<0.05). There were statistically significant differences between the two groups in birth weight-for-gestational age classification and postnatal feeding patterns(P<0.05). The results of multivariate logistic regression analysis revealed that low birth weight, exclusive formula feeding, mixed feeding, family history of allergy in first-degree relatives, cesarean delivery, and perinatal antibiotic exposure were perinatal risk factors for neonatal CMPA(P<0.05). Conclusion　Low birth weight, exclusive formula feeding,mixed feeding, family history of allergy in first-degree relatives, cesarean delivery, and perinatal antibiotic exposure are perinatal risk factors for neonatal CMPA.]]> 2026/9/30 9:59:16 1, Lu Siliang², Qiu Yanmei², Jing Lianfang², Wei Zhe³, Wu Kemou³, Li Yan²]]> ［Abstract］　Objective　To analyze the publication output, collaboration patterns, knowledge base, and thematic evolution of the studies on internal carotid artery associated with nasopharyngeal carcinoma. Methods　Articles and reviews were searched in the Web of Science Core Collection(WoSCC) database from its inception to July 14, 2026. Bibliometric and visualization analyses were performed using R 4.5.2 and VOSviewer 1.6.21 softwares. Results　A total of 253 publications were included. The annual publication volume showed a fluctuating upward trend from 1989 to 2025, with a third-order polynomial fit yielding an R² value of 0.865. China ranked first in publication output. Collaboration networks at the national, institutional, and author levels exhibited clustered patterns. Five clusters were identified based on high-frequency keywords, and 3 clusters were formed based on co-cited references, which primarily involved radiation-induced internal carotid artery injury, carotid blowout syndrome, and the treatment of recurrent nasopharyngeal carcinoma. Conclusion　The overall publication volume in this field shows a fluctuating growth trend. Research themes are primarily centered on the identification of vascular injuries, management of severe hemorrhage, and the assessment and protection of the internal carotid artery during the diagnosis and treatment of recurrent nasopharyngeal carcinoma.]]> 2026/9/30 9:59:16 ［Abstract］　This paper reports a case of concurrent pulmonary Nocardia terpenica infection during targeted therapy for lung adenocarcinoma.]]> 2026/9/30 9:59:16 1, Yu Chunhong², Du Yanjia¹, Zeng Zixiong¹]]> ［Abstract］　This paper reports a case of infective endocarditis and spondylitis caused by Streptococcus suis.]]> 2026/9/30 9:59:16 ［Abstract］　Objective　To analyze the risk factors and changing patterns of the sense of meaning in life in hemodialysis patients with diabetic nephropathy. Methods　A total of 94 hemodialysis patients with diabetic nephropathy who were admitted to the First Affiliated Hospital with Nanjing Medical University from April 2021 to October 2024 were selected as study participants. During the 0 to 12 weeks of hemodialysis treatment, the sense of meaning in life was measured every two weeks for the patients. Multivariate linear regression was used to analyze the factors influencing the sense of meaning in life of the hemodialysis patients with diabetic nephropathy at week 0 of hemodialysis treatment. MATLAB R2021a software was used to plot the variation curves of sense of meaning in life in the hemodialysis patients with diabetic nephropathy. Results　The scores of sense of meaning in life at week 0 of hemodialysis treatment were (35.41±3.61)points. The results of multivariate linear regression analysis showed that living alone, monthly household income less than 3,000 CNY, lack of physical activity, anxiety, and an educational level at junior high school or below were the influencing factors for the decline in the level of sense of meaning in life in the hemodialysis patients with diabetic nephropathy at week 0 of hemodialysis treatment(P<0.05). The scores of sense of meaning in life at weeks 2, 4, 6, 8, 10, and 12 of hemodialysis treatment were (38.73±2.85), (44.12±3.18), (51.24±4.32), (42.83±3.78), (39.48±2.46) and (37.82±3.26)points, respectively, showing a trend of first increasing and then decreasing. The variation curves of sense of meaning in life in the hemodialysis patients with diabetic nephropathy consisted of 3 parts: weeks 0-6(positive zone), weeks 6-8(stagnant and lingering zone) and weeks 8-12(negative zone). The positive zone represented the rising level of sense of meaning in life; the stagnant and lingering zone represented the stagnant and lingering period of sense of meaning in life, and the negative zone represented the continuously declining level of sense of meaning in life. Conclusion　Living alone, low monthly household income, lack of physical activity, anxiety, and low educational level are influencing factors for the declining level of sense of meaning in life in the hemodialysis patients with diabetic nephropathy at week 0 of hemodialysis treatment. The levels of sense of meaning in life in the hemodialysis patients with diabetic nephropathy show a trend of first increasing and then decreasing with the duration of hemodialysis. The sixth week is the optimal time point for intervention.]]> 2026/9/30 9:59:16 ［Abstract］　Molecular diagnostics has become an important means of pathogen detection. The nucleic acid amplification combined with clustered regularly interspaced short palindromic repeats(CRISPR) molecular detection system is regarded as a next-generation point-of-care molecular diagnostic technology. The CRISPR one-tube method integrates nucleic acid amplification and CRISPR detection into a single reaction system, which has attracted considerable attention from researchers. In recent years, nucleic acid amplification-CRISPR/CRISPR-associated proteins(Cas) one-tube method systems based on various biosensors for final signal measurement have been continuously developed, demonstrating potential applications in rapid pathogen detection, food safety, and environmental monitoring. In this paper, the advances in various biosensors based on nucleic acid amplification-CRISPR/Cas one-tube method are reviewed.]]> 2026/9/30 9:59:16 1, Cai Xiangjing¹, He Mianyun¹, Liu Runbiao¹, Lai Shiying¹, Zhang Pengfei¹, Xu Junfa^1,2]]> ［Abstract］　As a traditional and commonly used Chinese herbal medicine, Rhizoma Coptidis(Huanglian) exhibits significant intestinal protective and anti-inflammatory effects. The active components of Rhizoma Coptidis(such as berberine and palmatine) and its compound prescriptions can exert therapeutic effects through multiple pathways, including inhibiting key inflammatory signaling pathways, regulating intestinal immune homeostasis, enhancing intestinal barrier function, and remodeling the gut microbiota and metabolic balance. This paper reviews the research progress of pharmacological effects and clinical applications of Rhizoma Coptidis and its compound prescriptions in the treatment of anorectal diseases.]]> 2026/9/30 0:00:00 ［Abstract］　Stress urinary incontinence(SUI) has a high incidence in the female population, limiting the patients′ daily activities and significantly affecting their quality of life, imposing a heavy psychological and economic burden on the patients. Platelet-rich plasma(PRP) is a concentrate of platelets prepared by centrifugation of whole blood, containing various growth factors that promote cell proliferation, repair, and vascular regeneration, and has been widely applied in regenerative medicine. Currently, PRP, as an emerging treatment for SUI, has received widespread attention. This paper reviews the research progress of PRP in treatment of SUI.]]> 2026/9/30 9:59:17 1, Zhang Mingran², Jiang Tianhua¹]]>