| 摘要: |
| 目的:分析血清AFP、Ki-67水平联合阴道超声在卵巢成熟畸胎瘤鉴别诊断中的应用价值。方法:选取2023年1月~2024年7月我院收治的卵巢畸胎瘤患者作为研究对象,病例数为135例,并依据依据术后病理类型分为卵巢成熟畸胎瘤组(n=108)、卵巢未成熟畸胎瘤组(n=27)两组,进行病例对照研究,均进行阴道超声检测,并比较两组阴道超声结果、血清AFP、Ki-67表达水平。用Logistic回归分析影响卵巢成熟畸胎瘤的危险因素；通过绘制ROC曲线分析阴道超声、血清AFP、Ki-67水平对卵巢成熟畸胎瘤患者鉴别诊断中应用价值。结果:两组年龄、E2、LH、FSH相比(P＜0.05)；且与卵巢未成熟畸胎瘤组相比,卵巢成熟畸胎瘤组患者内膜厚度、3D-PDA参数、血清AFP、Ki-67水平均降低,螺旋动脉血流及子宫动脉的搏动指数、阻力指数升高,差异有统计学意义(P＜0.05)；最终Logistic回归模型分析显示,螺旋动脉血流、子宫动脉、内膜厚度、3D-PDA参数、AFP、Ki-67均是影响卵巢成熟畸胎瘤发生的危险因素(P＜0.05)。ROC曲线分析显示阴道超声、血清AFP、Ki-67联合诊断卵巢成熟畸胎瘤鉴别诊断价值最高(P＜0.05)。结论:阴道超声指标、血清AFP、Ki-67水平在卵巢成熟畸胎瘤患者中表达异常,ROC曲线分析显示阴道超声、血清AFP、Ki-67联合鉴别卵巢成熟畸胎瘤的诊断价值高于单项检测,在临床中可以将阴道超声、血清AFP、Ki-67三者联合应用。 |
| 关键词: 阴道超声 甲胎蛋白 增殖细胞核抗原 卵巢成熟畸胎瘤 |
| DOI： |
| 分类号: |
| 基金项目:陕西省重点研发计划项目：2022SF-2170 |
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| Value of serum Ki-67 and AFP levels combined with vaginal ultrasound in differentiating mature ovarian teratoma |
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丁鹍
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陕西省安康市中心医院
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| Abstract: |
| Objective: To analyze the value of serum AFP and Ki-67 levels combined with vaginal ultrasound in the differential diagnosis of mature ovarian teratoma. Methods: A total of 135 patients with ovarian teratoma admitted to our hospital from January 2023 to July 2024 were selected as the research subjects. According to the postoperative pathological types, they were divided into two groups: the mature ovarian teratoma group (n=108) and the immature ovarian teratoma group (n=27) for a case-control study. All patients underwent vaginal ultrasound detection. The vaginal ultrasound results, serum AFP and Ki-67 expression levels of the two groups were compared. Logistic regression was used to analyze the risk factors influencing mature ovarian teratoma; The application value of vaginal ultrasound, serum AFP and Ki-67 levels in the differential diagnosis of patients with mature ovarian teratoma was analyzed by drawing the ROC curve. Results: Comparison of age, E2, LH and FSH between the two groups (P < 0.05); Moreover, compared with the immature ovarian teratoma group, the endometrial thickness, 3D-PDA parameters, serum AFP and Ki-67 levels of patients in the mature ovarian teratoma group were all decreased, while the spiral artery blood flow and the pulsatility index and resistance index of the uterine artery were increased, and the differences were statistically significant (P < 0.05).Logistic regression analysis showed that age, E2, LH, FSH, spiral artery blood flow, uterine artery, endothelial thickness, 3D-PDA parameters, AFP, and Ki-67 were risk factors for the development of mature teratoma of the ovary (P < 0.05).ROC curve analysis showed that the combined diagnosis of mature teratoma of the ovary by vaginal ultrasound, serum AFP, and Ki-67 had the had the highest value (P < 0.05). Conclusions: The expression of vaginal ultrasound index, serum AFP and Ki-67 levels are abnormal in patients with mature ovarian teratoma. ROC curve analysis shows that the diagnostic value of vaginal ultrasound, serum AFP and Ki-67 in the differential diagnosis of mature ovarian teratoma is higher than that of single detection, and the combination of vaginal ultrasound, serum AFP and Ki-67 can be used in clinic. |
| Key words: vaginal ultrasound Alpha-fetoprotein Proliferating cell nuclear antigen Mature teratoma of ovary |
