| 摘要: |
| 目的? 探究血清同源框基因A10(HOXA10)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、细胞质聚腺苷酸化元件结合蛋白1(CPEB1)水平预测多囊卵巢综合征(PCOS)合并不孕症患者体外受精-胚胎移植(IVF-ET)后妊娠结局的临床价值。? 方法? 选择在本院接受IVF-ET后的PCOS不孕患者125例纳入IVF-ET组,根据妊娠结局分为妊娠组(58例)、未妊娠组(67例),另选择125例同期健康体检者纳入对照组。ELISA法检测血清HOXA10、GM-CSF、CPEB1水平；多因素Logistic回归分析影响IVF-ET后患者妊娠结局的因素；ROC曲线分析血清HOXA10、GM-CSF、CPEB1水平对IVF-ET后患者妊娠结局的预测价值。? 结果? 与对照组比较,IVF-ET组血清HOXA10、CPEB1水平表达上调,血清GM-CSF水平表达下调(P<0.05)；与妊娠组比较,未妊娠组雌二醇(E2)、GM-CSF水平显著下降,睾酮(T)、血HOXA10、CPEB1水平水平显著升高(P<0.05)；GM-CSF、HOXA10、CPEB1是影响患者未妊娠的相关因素(P<0.05)；血清HOXA10、GM-CSF、CPEB1水平单独预测妊娠结局的AUC分别为0.813、0.805、0.814,三者联合预测的AUC为0.944,优于三者单独预测(ZHOXA10-三者联合=3.514、ZGM-CSF-三者联合=3.547、ZCPEB1-三者联合=3.438,P均＜0.05)。? 结论? PCOS合并不孕症患者血清中HOXA10、CPEB1表达上调,GM-CSF表达下调,三者均是影响患者IVF-ET后妊娠结局的重要因素,联合对IVF-ET后妊娠结局的预测具有较高的临床价值。 |
| 关键词: 多囊卵巢综合征合并不孕症 粒细胞-巨噬细胞集落刺激因子 细胞质聚腺苷酸化元件结合蛋白1 同源框基因A10 体外受精-胚胎移植 妊娠结局 |
| DOI： |
| 分类号: |
| 基金项目:三门峡市2022年科技发展计划项目(编号:2022001006) |
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| Clinical value of serum HOXA10, GM-CSF, and CPEB1 in predicting pregnancy outcomes in patients with polycystic ovary syndrome combined with infertility after in vitro fertilization embryo transfer |
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纪雯雯
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| Abstract: |
| Objective: To explore the clinical value of serum homobox A10 (HOXA10), granulocyte-macrophage colony-stimulating factor (GM-CSF), and cytoplasmic polyadenylation element binding protein 1 (CPEB1) in predicting pregnancy outcomes after in vitro fertilization embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) combined with infertility. |
| Key words: Polycystic ovary syndrome combined with infertility Granulocyte-macrophage colony-stimulating factor Cytoplasmic polyadenylation element binding protein 1 Homobox A10 IVF-ET Pregnancy outcome |
