| 摘要: |
| EB病毒(EBV)是一种隶属于疱疹病毒家族的双链DNA病毒，其与多种疾病相关，如传染性单核细胞增多症、慢性活动性EBV感染及EBV相关自身免疫疾病等，主要感染人群为3岁至5岁的儿童。近年来，研究发现辅助性T细胞17(Th17)和调节性T细胞(Treg)的免疫失衡在EBV感染相关疾病的发生发展中起重要作用。Th17通过分泌IL-17等促炎因子，参与炎症反应和组织损伤；而Treg则通过免疫抑制作用维持免疫稳态。EBV通过调控宿主免疫应答，破坏Th17/Treg细胞平衡，进而引发免疫系统紊乱，为病毒的长期感染和相关疾病的进展提供了有利条件。本文将综述EBV的特点、Th17/Treg细胞的功能特点、EBV感染导致的免疫失衡机制及其在相关疾病中的研究进展。 |
| 关键词: 儿童 EB病毒 Th17 Treg Th17/Treg细胞平衡 |
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| 基金项目:常州市第十一批科技计划项目(应用基础研究专项-卫健领域社会资金资助项目<面上项目>)（编号：CJ20245010） |
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| Immunological Imbalance of Th17/Treg Cells in Epstein-Barr Virus-Associated Diseases |
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yangpengli
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The Third Affiliated Hospital of Soochow University
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| Abstract: |
| Epstein-Barr virus (EBV), a double-stranded DNA virus belonging to the herpesvirus family, is associated with a variety of diseases, including infectious mononucleosis, chronic active EBV infection, EBV-associated hemophagocytic lymphohistiocytosis, and EBV-related autoimmune disorders. Primary EBV infection predominantly occurs in children aged 3 to 5 years.
Recent studies have demonstrated that the dysregulation of T helper 17 (Th17) and regulatory T (Treg) cell balance plays a crucial role in the pathogenesis of EBV-associated diseases. Th17 cells secrete pro-inflammatory cytokines, such as IL-17, contributing to inflammatory responses and tissue damage, whereas Treg cells maintain immune homeostasis through immunosuppressive mechanisms. EBV infection disrupts Th17/Treg equilibrium by modulating host immune responses, leading to immune dysfunction. This imbalance facilitates viral persistence and promotes disease progression.This article reviews the characteristics of EBV, the functional roles of Th17 and Treg cells, the mechanisms underlying EBV-induced immune dysregulation, and recent advances in the understanding of EBV-associated diseases. |
| Key words: Children Epstein-Barr virus Th17 Treg Th17/Treg cell balance |
