| 摘要: |
| ［摘要］ Rh血型是继ABO血型发现后的临床意义最大的一个血型，也是最复杂、最富有多态性的红细胞血型系统。现代分子生物学研究证明，传统的Rh抗原是由RHD和RHCE两个基因编码，其中RHD基因编码RhD多肽，RHCE基因编码RhC/c和RhE/e多肽。Rh血型系统抗原抗体的不匹配能引起溶血性输血反应、新生儿溶血病和自身免疫性溶血性贫血。 |
| 关键词: Rh血型 分子生物学 输血 新生儿溶血病 |
| DOI： |
| 分类号:R 457.1 |
| 基金项目: |
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| Advance of Rh blood group system and its clinical application. |
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SHEN Wei-dong, TANG Qiu-min
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Nanning Blood Central Bank (Nanning Institute of Transfusion Medicine), Nanning 530003, China
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| Abstract: |
| ［Abstract］ The human Rh blood group system is one of the most clinically significant red blood cell system next to ABO, and as well the most complicated and polymorphic in blood group systems. Modern molecular biology studies have shown that Rh antigens are encoded by RHD and RHCE. Gene RHD is coding Rh D polypeptide, RHCE coding RHC/c and RHE/e, respectively. Incompatibilities of antigen-antibody in the Rh blood group system can cause hemolytic transfusion reactions, hemolytic disease of the newborn and autoimmune hemolytic anemia. |
| Key words: Rh blood group system Modern molecular biology Blood transfusion Hemolytic disease of newborn |
