| 摘要: |
| ［摘要］ 目的 分析原发性中枢神经系统淋巴瘤临床特点及误诊的原因。方法 对19例被手术、术后病理和免疫组化证实的原发性中枢神经系统淋巴瘤进行回顾性分析。结果 术前均误诊，其中误诊为胶质瘤8例，转移瘤4例，脑膜瘤5例，脱髓鞘疾病2例。根据术后病理及免疫组化结果，B细胞淋巴瘤18例，T细胞淋巴瘤仅1例。结论 临床表现无特异性, 术前误诊率高, CT和MRI表现有一定特点, 确诊依靠病理检查。脑活组织病理检查是确诊的惟一手段。 |
| 关键词: 中枢神经系统肿瘤 淋巴瘤 误诊 |
| DOI： |
| 分类号:R 739.41 |
| 基金项目: |
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| Clinical analysis of the cause of misdiagnosis in 19 patients with primary central nervous system lymphoma |
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WEI Feng, CHEN Jian, ZHU Sheng, et al.
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Department of Neurosurgery, the Second Hospital of Nanning, Nanning 530031, China
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| Abstract: |
| ［Abstract］ Objective To investigate the clinical features of primary central nervous system lymphoma (PCNSL) and its cause of misdiagnosis.Methods The date of 19 patients with PCNSL, which were confirmed by the operation and pathological and immunohistochemical examinations, were clinically analyzed retrospectively. Results All cases were misdiagnosed preoperatively. Of the misdiagnosed, 8 were diagnosed as neurospongioma, 4 as brain metastatic tumor, 5 as meningothelioma, and 2 as demyelinating disease. According to the pathological and the immunohistochemical examinations, 18 cases were B-cell lymphoma， only 1 case was T-cell lymphoma.Conclusion There are no specific clinical manifestations of PCNSL and the disease is often misdiagnosed preoperatively. Although certain characteristic performance may be found on CT and MRI scans, the final diagnosis of this disease depends on pathological examination. Comprehensive treatments may prolong the survival time of the patients. Brain biopsy with pathological examination may be the only reliable method to confirm the diagnosis. |
| Key words: Central nervous system neoplasm Lymphoma Misdiagnosis |
