| 摘要: |
| ［摘要］ 目的 观察清开灵注射液对脓毒症(sepsis)患者的抗炎作用。方法 将脓毒症患者60例随机分为治疗组与对照组各30例，两组均给予西药常规治疗，治疗组在常规治疗的基础上加用清开灵注射液治疗，观察两组治疗前后外周血单个核细胞核转录因子-κB（nuclear transcription factor，NF-κB）活性及肿瘤坏死因子-α(TNF-α)水平变化及并发症的发生情况。结果 治疗组治疗后外周血单个核细胞NF-κB活性及TNF-α水平明显下降，对照组则变化不大；治疗组并发症发生率明显低于对照组。结论 清开灵注射液对脓毒症患者炎症反应具拮抗作用，可阻断全身炎症反应综合征(SIRS)的病理反应过程，可改善脓毒症患者的预后。 |
| 关键词: 脓毒症 清开灵注射液 核转录因子-κB 肿瘤坏死因子-α |
| DOI： |
| 分类号:R 631 |
| 基金项目: |
|
| Antagonistic effects of Qingkailing injection on the inflammation reaction in the patients with sepsis |
|
LIAO Dian-chang
|
|
Emergency Department, Dapu County People′s Hospital, Dapu 514200, China
|
| Abstract: |
| ［Abstract］ Objective To explore the anti-inflammation effects of Qingkailing injection in treating sepsis.Methods Sixty patients with sepsis were randomly divided into the treatment group and the contrast group.Both groups were treated by normal westem medicine and Qingkailing injection was added to the treatment group. The activation of NF-κB and the level of TNF-α were examined by ELISA method in both group before and after the treatment, and the complications were observed in both group after the treatment.Results The activation of NF-κB and the level of TNF-α in the treatment group were decreased obviously after treatment while no diference was found in the contrast group.The occurrence ratio of complication in the treatment group was significantly lower than that in the contrast group. Conclusion Qingkailing injection can resist the inflammation reaction of sepsis，interdict the pathology response process of systemic inflammatory response syndrome(SIRS)and improve the prognosis of sepsis. |
| Key words: Sepsis Qingkailing injection Nuclear transcription factor Kappa B Tumor necrosis factor-α |
