| 摘要: |
| ［摘要］ 目的 探讨广西壮族不同程度慢性乙型病毒性肝炎（慢乙肝）的HLA-DQA1等位基因的相关性。方法 采用序列特异性引物-聚合酶链式反应（ssp-PCR）法检测壮族轻、中、重度各30例慢乙肝患者HLA-DQA1等位点并进行基因分析研究。结果 轻度、中度组HLA-DQA1*0103等位基因的频率较重度组明显升高；重度组HLA-DQA1*0301等位基因的频率较慢乙肝轻度组明显降低。结论 携带DQA1*0103等位基因个体感染HBV以后更易发展为轻、中度肝炎，而DQA1*0301可能为重度慢乙肝抗性基因。 |
| 关键词: 乙型病毒性肝炎 人类白细胞抗原 等位基因 壮族 |
| DOI：10.3969/j.issn.1674-3806.2009.03.002 |
| 分类号:R 512.6 |
| 基金项目:广西科技厅基金课题（桂科攻0238022） |
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| Study on the association of the HLA-DQA1 alleles with the different chronic hepatitis B of the Zhuang nationality in Guangxi Zhuang Autonomous Region |
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CHEN Zhi-ping, WEI Kang-lai，LI Ruo-lin, et al.
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School of Public Health, Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the association of the HLA-DQA1 alleles with the different chronic hepatitis B of the Zhuang nationality in Guangxi.Methods In thirty patients with mild 、moderate and severe chronic hepatitis B in Zhuang nationality in Guangxi the HLA-DQA1 alleles were identified by using the polymerase chain reaction-sequence specific primers(PCR-ssp) technique.Results The alleles gene frequencies of HLA-DQA1*0103 in the Zhuang patients with mild and moderate chronic hepatitis B was singnificantly higher than that in the patients with severe chronic hepatitis B;HLA-DQA1*0301 in the patients with severe chronic hepatitis B was lower than that in the patients with mild and moderate′s chronic hepatitis B.Conclusion So DQA1*0301 may be protective alleles of severe chronic hepatitis B in Zhuang nationality. |
| Key words: HBV HLA Allele Zhuang nationality |
