| 摘要: |
| ［摘要］ 目的 探讨癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)、细胞角蛋白19片断(CY21-1)、葡萄糖 (GLU)在结核性和恶性胸腔积液鉴别诊断中的价值。方法 用电化学发光免疫分析法定量测定42例肺癌伴胸腔积液（恶性）和54例结核性胸腔积液（良性）患者胸腔积液中CEA、NSE、CY21-1、GLU含量。结果 恶性胸腔积液组CEA、NSE、CY21-1、GLU均明显高于结核性胸腔积液组（P<0.05）。CEA、NSE、CY21-1敏感性分别为64.3%、26.2%、57%，特异性分别为94.4%、94.4%、80.4%；三项联合检测的敏感性为90.5%，特异性83.3%。结论 联合检测胸腔积液中CEA、NSE、CY21-1、GLU的含量对结核性和恶性胸腔积液的诊断和鉴别诊断有一定的价值。 |
| 关键词: 癌胚抗原(CEA) 神经特异性烯醇化酶(NSE) 细胞角蛋白19片断(CY21-1) 葡萄糖(GLU) 胸腔积液 |
| DOI：10.3969/j.issn.1674-3806.2009.04.012 |
| 分类号:R 730.43 |
| 基金项目: |
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| Clinical significance of CEA, NSE, CY21-1 and GLU in the differential diagnosis of tuberculous effusion and malignant pleural effusion |
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ZHANG Jin-hui, HUANG Li-xiao, WANG Qi
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Department of Respiratory Medicine, the second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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| Abstract: |
| ［Abstract］ Objective To explore the differential diagnosis value of CEA, NSE, CY21-1 and GLU in tuberculous effusion(TE) and malignant pleural effusion(MPE).Methods The levels of the four markers in 42 cases of MPE and 54 cases of TE were detected by electrochemilumin-escence immunoassay.Results The levels of four markers in MPE group were significantly higher than that in TE group（P < 0. 05）.The sensitivity for each marker of CEA, NSE, CY21-1 in the diagnosis of MPE was 64.3%, 26.2%, 57%, respectively， specificity was 94.4%, 94.4%, 80.4%, respectively. Combined three markers in the detections of in MPE, the sensitivity and specificity were 90.5% and 83.3%, respectively. Conclusion Combined detection of four markers of CEA, NSE, CY21-1 and GLU has significant value in the differential diagnosis of TE and MPE. |
| Key words: CEA NSE CY21-1 GLU Pleural effusion |
