| 摘要: |
| ［摘要］ 目的 评价小剂量环磷酰胺(CTX)与血浆置换(plasm exchange, PE)治疗重症系统性红斑狼疮(SLE)的临床疗效。方法 对我院收治的60例重症SLE患者分为治疗组和对照组，治疗组行小剂量CTX+PE治疗，对照组行大剂量CTX冲击治疗，观察两组治疗后临床症状（面部红斑、关节疼痛、发热）和活动性指标（抗ds-DNA抗体、ANA、Scr、24 h尿蛋白、血沉、补体C3）变化。结果 与对照组相比，治疗组临床症状缓解率高且快，活动性指标有显著性差异（P<0.05）。结论 血浆置换可较快地控制重症SLE活动，联合应用小剂量环磷酰胺，提高近期及远期临床疗效，降低副作用。 |
| 关键词: 小剂量 环磷酰胺 血浆置换 重症系统性红斑狼疮 |
| DOI：10.3969/j.issn.1674-3806.2009.06.10 |
| 分类号:R 593.24 |
| 基金项目:钦州市科学研究与技术开发计划项目（合同编号：20073704） |
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| Small dosage of cyclophosphamide and plasm exchange in treating serious systematic lupus erythematosus |
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HUANG Wei-hua, NING Jun, HUANG Yi-jiang, et al.
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Department of Nephrology, First People′s Hospital of Qinzhou City, Guangxi 535000, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the clinical effectiveness of small dosage cyclophosphamide (CTX) and plasm exchange (PE) in treating serious systematic lupus erythematosus (SLE).Methods Sixty patients with serious SLE in our hospital were divided into treating group and contrast group. Small dosage of CTX + PE treatment was applied to patients in the treating group, while large dosage of CTX impulse treatment was applied to patients in the contrast group. The clinical symptom (erythema in the face, pain in the joints, febricity) and index in activities (anti-ds-DNA antibody, ANA, Scr, 24-hour urinary protein, erythrocyte sedimentation rate, and complement C3) changes after treatment were observed. Results Compared with the contrast group, the releasing rate of clinical symptom in the treating group was higher and faster, the index of activities was of significant difference (P<0.05). Conclusion Plasm exchange could rapidly control the activity of serious SLE, combined with application of small dosage cyclophosphamide would improve the short term and long term clinical effectiveness, and decrease side effects. |
| Key words: Small dosage Cyclophosphamide Plasm exchange Serious systematic lupus erythematosus |
