| 摘要: |
| ［摘要］ 肾母细胞瘤（Wilms tumor，WT）是小儿常见的恶性实体肿瘤，随着放疗、化疗和手术治疗水平的进步极大提高了WT的生存率，尽管如此，仍有部分患儿预后不佳，肿瘤复发、转移和化疗失败是主要原因。肿瘤的复发和转移，对化疗药物的不敏感与肿瘤的血管生成调节和多药耐药有关，该文总结了目前WT所研究的血管生成调节因子和多药耐药因子及其作用机制，为提高该症的治疗效果提供基础研究参考。 |
| 关键词: Wilms瘤 血管生成调节剂 多药耐药相关蛋白质类 预后 |
| DOI：10.3969/j.issn.1674-3806.2009.06.47 |
| 分类号:R 737.11 |
| 基金项目: |
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| Reaserch of vascularization regulatory factor and multidrug resistence in Wilms tumor |
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DONG Chun-qiang
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Department of Pediatric Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Wilms tumor(WT) is the most common malignent renal solid tumor in children. Dramatic improvements in survival have occurred as the result of advances in surgical management, irradiation and chemotherapy, however some cases are in poor prognisis and recidivation, metastasis and the fail of chemotherapy are the main cause. The tumor′s recidivation, metastasis and insensitivty to chemotherapy are correlated with vascularizative regulatoy and multidrug resistence.With the purpose of improving the therapeutic effect and survival, this article summarize current researches in WT and their mechanism of action. |
| Key words: Wilms tumor Angiogenesis inducing agents Multidrug resistance-associated proteins Prognosis |
