| 摘要: |
| ［摘要］ 目的 探讨核型BAG-1在早期乳腺癌组织中的表达与传统预后因素如临床病理特征、ER、PR、HER2的关系及其意义。方法 用免疫组化二步法检测76例有完整随访资料的早期乳腺癌患者乳腺癌组织中核型BAG-1、ER、PR及HER2的蛋白表达，并进行统计学分析。结果 核型BAG-1在早期乳腺癌组织中的阳性率为14.47%。核型BAG-1表达与患者的年龄、绝经状态、肿瘤的病理类型及HER2的蛋白表达无关(P>0.05)，与ER、PR蛋白表达相关(P<0.05)。单因素分析显示核型BAG-1、ER、HER2与预后相关，多因素分析显示只有核型BAG-1表达与预后相关。结论 核型BAG-1与ER、PR相关，可能作为早期乳腺癌预后判断的指标之一。 |
| 关键词: 核型BAG-1 ER 早期乳腺癌 预后 |
| DOI：10.3969/j.issn.1674-3806.2009.10.01 |
| 分类号:R 737.9 |
| 基金项目:广西壮族自治区卫生厅重点科研课题(重200313) |
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| Expression and significance of nuclear BAG-1 in early breast cancer |
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QIN Yu-zhou, OU Hai-ling, LIU Jian-lun
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Department of Gestrointestine and Breast, Guangxi Cancer Hospital, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe retrospectively the expression and significance of nuclear BAG-1 in early breast cancer(EBC) and its relationship with clinical pathological features and ER, PR, HER2.Methods A total of 76 patients with EBC were followed up in this study. The protein expressions of nuclear BAG-1, ER, PR and HER2 in these patients were detected by immunohistochemical two-step method and statistically analyszed.Results The positive rate of protein expression of nuclear BAG-1 was 14.47%. The protein expression of nuclear BAG-1 was not related to age, menopausal status, histology and HER2(P>0.05), but positively related to PR and ER(P<0.05). Nuclear BAG-1、ER、HER2 were correlated with prognosis in univariate analysis with COX proportional hazard model. In multivariate analysis, only nuclear BAG-1 was correlated with prognosis.Conclusion The results of this small pilot study suggest that the protein expression of nuclear BAG-1 in EBC was correlated with ER and PR, that might be a novel prognostic biomarker. |
| Key words: Nuclear BAG-1 ER Early breast cancer(EBC) Prognosis |
