| 摘要: |
| ［摘要］ 目的 探讨氟尿嘧啶(5-FU)使用微量泵持续滴注192 h治疗恶性滋养细胞肿瘤的临床疗效和毒副反应。方法 35例恶性滋养细胞肿瘤患者行持续192 h滴注5-FU方案治疗。32例恶性滋养细胞肿瘤患者行常规滴注5-FU, 第1～8天方案治疗, 对两组进行临床对比观察。结果 持续滴注组有效率为51.4%, 常规滴注组有效率为25.0%, 两组疗效比较差异有显著性。常规滴注组毒副反应较持续滴注组发生率高, 主要为骨髓抑制、恶心呕吐等。结论 持续滴注5-FU治疗恶性滋养细胞肿瘤的临床疗效优于常规滴注；毒副反应明显低于常规滴注。 |
| 关键词: 滋养细胞肿瘤 化疗 微量泵 |
| DOI：10.3969/j.issn.1674-3806.2009.10.18 |
| 分类号:R 737.3 |
| 基金项目: |
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| The clinical observation on micro pump application in the chemotherapy of nutrient cell tumor |
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YU Ying, ZHANG Qun-gui
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Department of Gynecology, Ganzhou Tumor Hospital, Jiangxi 341000, China
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| Abstract: |
| ［Abstract］ Objective To discuss the clinical curative effect and the poisonous side reaction of 192 hour continuous drop of fluorine uracil (5-FU) by micro pump in the treatment of malignant nutrient cell tumor.Methods Thirty-five malignant nutrient cell tumor patient received 192 hours continuous drops of 5-FU, the 1～8th day plan treatment;32 malignant nutrient cell tumor patient received convention vein drop of 5-FU, the 1～8th day plan treatment; and the clinical contrast observation were performed.Results The effective rate in continuous drop group was 51. 4%， the effective rate in conventional vein drop group was 25. 0%, the difference in of curative effect between two groups had significance.Compared with the continuous vein drop group, the poisonous side reaction (mainly marrow suppression, nausea vomit and so on) rate of the conventional vein drop group was higher.Conclusion The clinical curative effect of continuous drop of the 5-FU in the treatment of malignant nutrient cell tumor surpasses the conventional drop treatment； the poisonous side reaction is obviously lower than the conventional drop treatment. |
| Key words: Nutrient cell tumor Chemotherapy Micro pump |
