| 摘要: |
| ［摘要］ 急性肾损伤是指肾脏功能或结构方面的异常（包括血、尿、组织检测或影像学方面的肾损伤标志物异常），时限不超过3个月。AKI的诊断标准为：肾功能在48 h内突然减退，表现为血肌酐升高，绝对值≥26.4 μmol/L；或血肌酐较基础值升高≥50%；或尿量减少［尿量<0.5 ml/（kg·h），时间超过6 h者］。血肌酐及尿量仍是目前诊断AKI的重要指标。无创性、高度敏感及特异性、能区分AKI病因的生物学标志物是目前AKI研究的热点。尽管包括对症支持治疗和肾替代治疗方法有改进，但AKI仍保持较高的死亡率。 |
| 关键词: 急性肾损伤 生物标志物 肾替代治疗 |
| DOI：10.3969/j.issn.1674-3806.2009.10.47 |
| 分类号:R 692.5 |
| 基金项目: |
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| Progress in the diagnosis and treatments of acute kidney injury |
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TANG Ge, PENG Xiao-mei
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Department of Nephrology, Qinzhou Second People′s Hospital, Guangxi 535000, China
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| Abstract: |
| ［Abstract］ Acute kidney injury (AKI) is a common clinical problem defined by an abrupt (within 48 hours) increase in serum creatinine resulting from an injury or insult that causes a functional or structural change in the kidney. Serum creatinine and urine output are common measures reflecting renal function. Currently, there is a lack of sensitive and specific markers for kidney injury available in clinical practice although several kidney-specific biomarkers are under development. Despite substantial technical improvements in treatments, mortality and morbidity associated with acute renal failure remain high. |
| Key words: Acute renal failure Biomarkers Renal replacement |
