| 摘要: |
| ［摘要］ 目的 探讨超声测量胎儿颈背皮肤透明带厚度（nuchalskinfold thickness, NT）在染色体异常疾病21-三体综合征筛查的应用价值。方法 经腹超声测量孕12～27周孕妇1500例胎儿颈背皮肤透明带厚度，并与染色体核型分析及随访后结果作对照。结果 1 500例胎儿中，21-三体综合征的发病率为3.3‰，其中NT增厚者有62例，其中4例为21-三体综合征；无NT增厚中，有1例21-三体综合征。敏感性为80%，特异性为96.07%，准确性为96.12%，阳性预测值为6.45%。结论 NT检测对于21-三体综合征的早期诊断具有重要的意义，是早中期妊娠阶段产前筛查有效可行的方法。 |
| 关键词: 21-三体综合征 B超 NT 产前筛查 |
| DOI：10.3969/j.issn.1674-3806.2009.12.04 |
| 分类号:R 714.5 |
| 基金项目:广西壮族自治区科技厅科技攻关与开发资助项目(桂科攻9817095) |
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| The study of nuchalskinfold thickness (NT) by ultrasonic B in screening Down syndrome at early and middle stage pregnancy |
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MO Wei-ying, WAN Li-kai, CHEN Yan-hong
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Reproductive medical and genetic center, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To assess the value of nuchalskinfold thickness (NT) by ultrasonic B in screening Down syndrome at early and middle stage pregnancy.Methods Nuchalskinfold thickness (NT) of 1500 pregnant women (12～27weeks) were detected by ultrasonic B, and results were compared with chromosomal karyotypes analysis and follow-up visit of each pregnant woman.Results In 1 500 cases incidence of Down syndrome was 3.3‰, and 62 cases were high-risk for NT by ultrasonic B and including 4 Down syndrome cases;in low-risk for NT cases, 1 Down syndrome case were found. The NT sensitivity to Down syndrome was 80%, specificity was 96.07%, accuracy was 96.12% and the positive predictive rate was 6.45%.Conclusion Detection of NT by ultrasonic B may play an important role in screening Down syndrome at early and middle stage pregnancy. |
| Key words: Down syndrome Ultrasonic B Nuchalskinfold thickness (NT) Postnatal screening |
