| 摘要: |
| ［摘要］ 目的 对比非甾体类药物（NSAIDs）、透明质酸钠(HA)、骨髓间质干细胞(BMSCs)三种方法治疗膝骨关节炎各个时期的疗效。方法 对60例关节镜下确诊为膝骨关节炎的病人随机分3组，分别用：（1）术后用NSAIDs治疗2～4周；（2）术后注射HA 1～2疗程；（3）术后取髂脊骨髓进行分离培养出BMSCs再进行回植到膝关节中等3种方法治疗。分别在术后3个月、1年、3年的时间进行随访、并用WOMAC指数评分法对膝关节功能进行评价，两两对比组间的治疗效果。结果 3个月随访显示3组在治疗结果方面差异无统计学意义（P>0.05）；1年随访显示HA组和BMSCs组与NSAIDs组相比治疗结果差异有统计学显著意义（P<0.05）；3年随访显示3组间治疗效果都有统计学显著差异。结论 3种方法对骨关节炎的早期疗效都较好，但BMSCs的长期效果要优于其他2种方法。 |
| 关键词: 骨关节炎 骨髓间质干细胞 对比研究 |
| DOI：10.3969/j.issn.1674-3806.2009.12.08 |
| 分类号:R 684.3 |
| 基金项目:广西壮族自治区应用基础研究基金项目（桂科基0342054） |
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| Bone marrow mesenchymal stem cell transplantation for treatment of knee osteoarthritis:A comparative study |
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XU You-gao, HU Jv-zheng, WANG Yong, et al.
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Joint Surgery Liuzhou Workers Hospital, Guangxi 545005, China
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| Abstract: |
| ［Abstract］ Objective To compare the efficacy of non-steroidal drugs (NSAIDs), hyaluronic acid (HA), bone marrow mesenchymal stem cells (BMSCs) for knee osteoarthritis of various periods.Methods Sixty patients with knee osteoarthritis confirmed by arthroscopic operation were randomly divided into 3 groups : (1)NSAIDs group was treated with NSAIDs for 2～4 weeks after operation;(2)HA group was treated by injection of HA 1～2 courses after operation;(3)BMSCs group was treated by intra-articalar replantation of BMSCs obtained by means of isolation and culture of iliac crest bone marrow. The knee joint function were evaluated by WOMAC index scores, 3 months, 1 year, 3 years after surgery.Pairwise comparison between the three groups were performed.Results 3 months follow-up showed the treatment results of three groups was not statistically difference; 1 year follow-up showed in comparison of HA group and the BMSCs group with the NSAIDs the treatment results were statistically difference; 3-year follow-up showed three groups were statistically difference between the treatment effect.Conclusion The early efficacy of three kinds of methods for osteoarthritis are good, but the long-term effects of BMSCs group is superior to the other 2 methods. |
| Key words: Osteoarthritis Bone marrow mesenchymal stem cells Comparative study |
