| 摘要: |
| ［摘要］ 目的 研究盐酸法舒地尔对蛛网膜下腔出血迟发性血管痉挛的防治作用。方法 以尼莫地平为对照，将55例蛛网膜下腔出血患者随机分为尼莫地平治疗组（n=15）、法舒地尔治疗组(n=20)及法舒地尔联合尼莫地平治疗组(n=20)。应用经颅多普勒动态观察发病后3、7、14、21、28 d的血流动力学变化、血压变化及Glasgow预后量表评分。结果 三组均能改善蛛网膜下腔出血迟发性血管痉挛和预后，且组间比较差异无统计学显著意义，但尼莫地平治疗组和联合治疗组低血压发生率大于法舒地尔治疗组。结论 盐酸法舒地尔对蛛网膜下腔出血迟发性血管痉挛的防治作用与尼莫地平相当，两者联用效果并不增强，但是盐酸法舒地尔对血压的影响较尼莫地平小。 |
| 关键词: 盐酸法舒地尔 尼莫地平 蛛网膜下腔出血 血管痉挛 |
| DOI：10.3969/j.issn.1674-3806.2009.12.15 |
| 分类号:R 743.35 |
| 基金项目: |
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| Effection of fasudil hydrochloride on delayed cerebral vasospasm after subarachnoid hemorrage |
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ZHANG Jin-hua, ZHAO Yan, JING Hong-jian, et al.
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Intensive Care Unit of Nuerological Department, the 1st People′s Hospital of Kaifeng City, Henan 475000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the clinical effect of fasudil hydrochloride on delayed cerebral vasospasm after subarachnoid hemorrage.Methods Fifty-five patients were randomly divided into 3 groups: nimodipine group(n=15), fasudil group(n=20) and drugs combination group(n=20). Transcranial Doppler was performed at 3, 7, 14, 21, 28 days after onset.Blood pressure and Glasgow outcome scale were also evaluated.Results Cerebral vasospasm were relieved and outcome were improved in the three groups, and there was no statistic difference among them.But incidence rate of low blood pressure in fasudil group was lower than that in both drug combination group and nimodipine group.Conclusion The effect of fasudil hydrochloride on delayed cerebral vasospasm after subarachnoid hemorrhage was equivalent to nimodipine. The effect of fasudil-nimodipine combination were not enhanced.The influence of fasudil hydrochloride on blood pressure is lighter than nimodipine. |
| Key words: Fasudil hydrochloride Nimodipine Subarachnoid hemorrage Vasospasm |
