| 摘要: |
| ［摘要］ 目的 探讨中药“补气解毒汤”治疗育龄妇女孕前TORCH活动性感染的作用机制。方法 选取TORCH-IgM阳性的孕前育龄妇女39例作为观察组，选取20例TORCH-IgM阴性的健康妇女作为对照组，采用ELISA法检测TORCH-IgM阳性患者治疗前后及健康对照组妇女血清TNF-α（肿瘤坏死因子-α）和IL-2（白细胞介素-2）的水平。结果 治疗前TORCH感染患者TNF-α及IL-2水平与对照组比较差异有统计学显著意义（P<0.05），TNF-α较对照组高，而IL-2水平较对照组低；经“补气解毒汤”治疗达临床治愈的TORCH患者TNF-α和IL-2水平与对照组比较差异无统计学意义（P>0.05）。结论 “补气解毒汤”能在体内通过提高机体免疫功能而发挥抗TORCH感染作用，它能使机体内TNF-α及IL-2恢复到正常水平，以此修复机体的免疫功能，这可能是“补气解毒汤”作用于TORCH活动性感染的作用机制。该研究为临床开发治疗TORCH活动性感染的中药提供了理论依据。 |
| 关键词: 中药补气解毒汤 TORCH感染 肿瘤坏死因子-α（TNF-α） 白细胞介素-2(IL-2) |
| DOI：10.3969/j.issn.1674-3806.2010.01.05 |
| 分类号:R 511;R 531 |
| 基金项目:柳州市科技基金资助项目（项目编号：200721304） |
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| The changes of TNF-α and IL-2 in serum of childbearing aged women with pre-pregnant TORCH infection treated with Chinese medicine Buqi Jiedu Decoction |
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OU Qi-wen,WANG Qiong,MO Ke-liang,et al.
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Liuzhou Population and Family Planning Service Center,Guangxi 545001,China
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| Abstract: |
| ［Abstract］ Objective To investigate the mechanism of Chinese medicine Buqi Jiedu Decoction in the treatment of childbearing aged women with pre-pregnant active TORCH infection.Methods Thirty-nine childbearing aged women with pre-pregnancy TORCH-IgM-positive infection were selected as observed group other 20 TORCH-IgM-negative healthy women as control group, using ELISA to detect the level of tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) in serum of TORCH-IgM-positive patients before and after treatment and healthy women in the control group.Results Before treatment,there was statistical significance in the differences of the level of TNF-α and IL-2 between TORCH patients and the control group（P<0.05）,the level of TNF-α in TORCH patients was higher than that in the control group, while the level of IL-2 in TORCH patients was lower than that in the control group. There was no statistical significance in the differences of the level of TNF-α and IL-2 between TORCH patients with clinical cure and the control groupe(P> 0.05).Conclusion Buqi Jiedu Decoction can exert the role of anti-TORCH infection by enhancing immune function,it can make the level of TNF-α and IL-2 returned to normal levels in order to repair the body′s immune function.This may be the mechanism of Buqi Jiedu Decoction in active TORCH infection, it also provide a theoretical basis of Chinese medicine in clinical development for the treatment of TORCH infections. |
| Key words: Chinese medicine Buqi Jiedu Decoction TORCH infection IL-2 TNF-α |
