| 摘要: |
| ［摘要］ 目的 探讨急性淋巴细胞白血病（ALL）患者染色体异常及免疫分型与疗效的关系。方法 对49例ALL患者骨髓进行染色体及免疫分型分析。结果 儿童ALL伴有t(9;22)异常核型的检出率明显低于成人ALL(P<0.05),但疗效差异无统计学意义(P>0.05);伴有t(9;22)的异常核型与正常核型ALL疗效比较差异有统计学显著意义(P<0.05);伴或不伴有髓系抗原表达的ALL疗效比较差异无统计学意义(P>0.05)。结论 ALL患者染色体核型异常的检出率较高，较常见的核型异常为t(9;22)；核型异常与疗效有一定的关系，伴有t(9;22)核型异常的ALL疗效差，而其它异常核型的ALL疗效间差异无统计学意义(P>0.05)。 |
| 关键词: 白血病 染色体核型 免疫分型 |
| DOI：10.3969/j.issn.1674-3806.2010.02.10 |
| 分类号:R 733.71 |
| 基金项目: |
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| Karyotype and immunophenotype analysis in 49 cases of acute lymphocytic leukemia |
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CHEN Zheng-li, NING Zi-jue, LIU Bo,et al.
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Experimental Department of Clinical Medicine, the First Affiliated Hospital of Guangxi Medical University，Nanning 530021，China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship between the efficacy and the karyotype and immunophenotype in acute lymphocytic leukemia (ALL). Methods A total of 49 bone marrow samples were taken for the karyotype and immunophenotype analysis. Results The detected rate of abnormal karycotype with t(9;22) in ALL children was significantly lower than that in ALL adult (P<0.05), but no difference in efficacy (P> 0.05); There was differences in efficacy between the abnormal karyotype with t(9;22) and normal karyotype (P<0.05); There was no difference in efficacy between acute lymphocytic leukemia with and without myeloid antigen expression (P> 0.05). Conclusion There was a higher rate of abnormal chromosome karycotype in patients with ALL, the more common chromosomal abnormal karycotype was t(9;22). There was a relationship between chromosomal abnormal karycotype and the efficacy. The efficacy was poorer in chromosomal abnormal karycotype accompanied by t(9;22) in ALL, while there was no difference in efficacy between other abnormal karyotypes in ALL. |
| Key words: Leukemia Chromosome karyotype Immunophenotype |
