| 摘要: |
| ［摘要］ 目的 研究子痫前期孕妇的甲状腺功能变化及对胎儿发育的影响。方法 采用病例对照研究方法，检测子痫前期（pre-eclamptic，PE）患者及新生儿促甲状腺激素（TSH）、总甲状腺素（TT4）、游离甲状腺素（FT4）、总三碘甲腺原氨酸（TT3）、游离三碘甲腺原氨酸（FT3）水平，入院时采用B超检测胎儿发育状况，进行胎儿生物物理4项评分（BPS）。结果 早发PE、晚发PE患者TSH水平均有显著性升高，胎儿BPS分值均显著性降低，早发PE患者FT3、FT4水平降低，晚发PE患者仅FT4水平降低。早发PE组新生儿各项激素水平均低于对照组。结论 子痫前期伴有甲状腺功能改变者，对胎儿发育会产生不利影响。 |
| 关键词: 子痫前期 甲状腺激素 胎儿生物物理评分 |
| DOI：10.3969/j.issn.1674-3806.2010.02.12 |
| 分类号:R 714.24 |
| 基金项目: |
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| Maternal and neonatal thyroid hormonal status study on early-onset and late-onset pre-eclampsia |
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CAI Feng-er,CAI Chun-fang
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Boai Hospital of Zhongshan City，Guangdong 528403,China
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| Abstract: |
| ［Abstract］ Objective To study maternal and neonatal thyroid hormonal status in pre-eclampsia.Methods Maternal and neonatal thyroid hormonal status including thyroid-stimulating hormone(TSH), total thyroxin(TT4), free thyroxin(FT4), total triiodothyronine(TT3), free triiodothyronine(FT3) were tested and biophysical profile score(BPS) was performed at the time of admission.Results TSH level was significantly increased in early-onset and late-onset pre-eclampsia with BPS significantly decreased. FT3 and FT4 level were significantly decreased in early-onset pre-eclampsia. Neonatal thyroid hormonal level was decreased in early-onset pre-eclampsia.Conclusion Thyroid hormonal status of pregnancy with pre-eclampsia is abnormal and it has adverse effects on the development of the fetus. |
| Key words: Pre-eclampsia Thyroid hormone Biophysical profile score |
