| 摘要: |
| ［摘要］ COX是前列腺素一类物质生成的限速酶，COX-2被认为主要与炎症等过程中PG的生成相关，与动脉粥样硬化的发生发展正相关。但选择性COX-2抑制剂的使用却增加了心血管事件的发生。其原因PGI2和TAX2的比例失衡学说被广泛接受。近年研究表明选择性的COX-2抑制剂尚有许多其他新的作用及副作用，因此极有必要对选择性的COX-2抑制剂的作用做一新的评判。 |
| 关键词: 选择性COX-2抑制剂 心血管事件 重新评判 |
| DOI：10.3969/j.issn.1674-3806.2010.03.38 |
| 分类号:R 543.5 |
| 基金项目: |
|
| The re-evaluation of the mechanism of cardiovascular events caused by the selective COX-2 inhibitors |
|
CHEN Li-feng,XU Tong-tong,ZHU Hua
|
|
Special Requirement Ward, Affiliated Hospital of Guilin Medical College, Guangxi 541001,China
|
| Abstract: |
| ［Abstract］ COX is a rate-limiting enzyme in generation of prostaglandins. It is considered COX-2 is primarily releted to the generation of prostaglandins in the process of inflammation and positively releted with the occurrence the development of atherosclerosis. However, selective COX-2 inhibitors have increased the incidence of cardiovascular events. The reason for the imbalance between PGI2 and TAX2 doctrine has been widely accepted. In recent years, studies have shown that selective COX-2 inhibitors has many other new roles and side effects, there is a great need for doing a new judgement on the role of selective COX-2 inhibitors. |
| Key words: Selective COX-2 inhibitors Cardiovascular events Re-assessment |
