| 摘要: |
| ［摘要］ 目的 探讨高渗晶体/胶体液在围手术期改善第三间隙积液的临床影响。方法 对2006-08～2009-01间44例胃肠道癌根治术病人，研究组（n=22）输注高渗晶体/胶体液后续晶体液等常规治疗，对照组（n=22）仅给予常规治疗。比较两组病人的输液量、尿量、液体平衡、血浆总蛋白及白蛋白的变化。结果 两组病人术中、术后第一个24 h、术后第二个24 h、术后第三个24 h的输入液量、术前及术后第1天总蛋白、白蛋白比较差异无统计学意义（P>0.05）。术中及术后第三个24 h尿量差异也无统计学意义（P>0.05）。但两组术后第一个24 h和术后第二个24 h的尿量差异有统计学意义（P<0.05），即研究组术后第一个24 h尿量明显较对照组多，对照组术后第二个24 h尿量较研究组多。结论 高渗晶体/胶体液临床用药安全，在胃肠道癌根治术围手术期具有促进尿量峰值提前出现、明显改善减少第三间隙积液的作用。 |
| 关键词: 高渗液 液体平衡 围手术期 |
| DOI：10.3969/j.issn.1674-3806.2010.04.01 |
| 分类号:R 459.3 |
| 基金项目:吴孟超医学科技基金会容量治疗专项基金资助项目（编号：C2005018） |
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| Effects of hypertonic saline/colloid on the effusion of third space during perioperative period |
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MAI Wei, MAN Xiao-bo,HUANG Shun-rong,et al.
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Department of General Surgery,the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To study the effects of hypertonic saline/colloid on fluid balance and clinical outcome during perioperative period.Methods forty-four patients with gastrointestinal carcinoma undergoing radical surgery were studied. The pairing patients were assigned to receive either hypertonic saline/colloid (the experimental group, n=22) or conventional solution(the control group, n=22)during the early postoperative period. Fluid infusion volumes, urine outputs, as well as total plasma protein, total albumin were compared between the two groups.Results Urine outputs during the first postoperative 24 hours in experimental group were significantly more than that in control group, but urine outputs in the third postoperative 24 hours in experimental group were significantly less than that in control group（P<0.05）. Fluid infusion volumes during the operation, the first postoperative 24 hours, the second postoperative 24 hours and second postoperative 24 hours in experimental group were no significantly different from that in control group（P>0.05）. Urine outputs during the intrapostoperative period and the third postoperative 24 hours were no significantly different from that in control group（P>0.05）. Total protein and total albumin on the preoperative day and the first postoperative day in experimental group were no significantly different from that in control group（P>0.05）.Conclusion Hypertonic saline/colloid has an intense diuretic effect, which could accelerate appearance of the top of urine outputs more early after the surgery, as well as reduce the effusion of third space after radical surgery for gastrointestinal carcinoma. |
| Key words: Hypertonic fluid Fluid balance Perioperative period |
