| 摘要: |
| ［摘要］ 目的 探讨早期高频震荡通气（HFOV）治疗新生儿呼吸窘迫综合征(RDS)的通气效果及临床疗效。方法 将46例RDS患儿随机分成两组各23例，分别采用HFOV治疗和常频机械通气（CMV）治疗，比较两组患儿的肺功能变化、临床疗效及并发症。结果 HFOV治疗组患儿在治疗2 h时动脉血氧分压（PaO2）及动脉二氧化碳（PaCO2）出现改变，经治疗6 h后,氧浓度(FiO2)、氧合指数(OI)显著下降,动脉/肺泡氧分压(a/APO2)明显上升,与治疗前对比差异有统计学意义(P<0.01),CMV组在治疗6 h后PaO2、PaCO2和OI等指标，与开始治疗时比较，差异有统计学意义(P<0.05);HFOV组与CMV组治疗至同一时间比较，差异有统计学意义(P<0.05或P<0.01)。HFOV组支气管肺发育不良(BPD)、肺气漏并发症低于CMV组,差异有统计学意义(P<0.05)，颅内出血（IVH）发生率差异无统计学意义(P>0.05)。存活患儿的氧疗时间、住院时间HFOV组比CMV组为短,差异有统计学意义(P<0.05)。结论 HFOV组能更快、更好地改善RDS患儿的肺氧合功能,通气效果、病程及并发症发生率等明显优于CMV组，早期应用于RDS治疗具有很好的疗效。 |
| 关键词: 高频震荡通气 呼吸窘迫综合征 婴儿 新生儿 |
| DOI：10.3969/j.issn.1674-3806.2010.09.12 |
| 分类号:R 722.12 |
| 基金项目: |
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| Clinical study of early high frequency oscillatory ventilation in the treatment of neonatal respiratory distress syndrome |
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LIANG Wu-hua
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Department of Newborn,Yulin Women and Child Health Hospital，Guangxi 537000，China
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| Abstract: |
| ［Abstract］ Objective To investigate the ventilation effect and clinical efficacy of early high frequency oscillatory ventilation (HFOV) in the treatment of neonatal respiratory distress syndrome (RDS).Methods Forty-six children patients with RDS were randomly divided into two groups. Of them, 23 children patients were treated with HFOV(HFOV group), 23 children patients with normal frequency mechanical ventilation (CMV) treatment(CMV group).The lung function, the clinical efficacy and complications in two groups were compared.Results In HFOV group the arterial oxygen pressure (PaO2) and arterial carbon dioxide (PaCO2) underwent changes at 2 h of the treatment.After 6 h after treatment, oxygen concentration (FiO2), oxygenation index (OI) were significantly decreased; arterial/alveolar oxygen partial pressure (a/APO2) significantly increased. Compared with those before treatment there was a significant difference (P<0.01).In CMV group, compared with those before the treatment, there is a significant difference in PaO2, PaCO2 and OI and other indicators after 6 h of treatment (P<0.05);When the treatment reached to the same time, HFOV group compared with the CMV group,there was significant difference in above indexes between two groups (P<0.05 or P<0.01).The incidence of bronchop ulmonary dysplasia (BPD) and pulmonary barotrauma complications in HFOV group were lower than those in CMV group. There was significant difference (P<0.05).In survival children, the time of oxygen therapy and hospital stay in HFOV group were shorter than those in the CMV group, the difference was significant (P<0.05).Conclusion Compared with CMV,HFOV has advantages such as faster,and better, oxygenation improvement in children with RDS function, better ventilation effect, shortern course of disease, and less incidence of complications. It has good efficacy in the treatment of early RDS. |
| Key words: High-frequency oscillatory ventilation Respiratory distress syndrome Infant Newborn |
