| 摘要: |
| ［摘要］ TOLL样受体（toll-like receptors,TLRs）在连接天然免疫和获得性免疫中起重要作用，它们通过多种信号转导识别外来微生物，越来越多的研究表明TLRs会促成多种自身免疫病（系统性红斑狼疮、类风湿关节炎等）的发生，而且在疾病的发病机理中起作用，相信随着研究的深入将会揭开自身免疫病发病机理，从而指导临床治疗。 |
关键词: 自身免疫病 TOLL样受体
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| DOI：10.3969/j.issn.1674-3806.2010.10.44 |
| 分类号:R 593.24 |
| 基金项目:常州市科技发展计划项目（编号：CS20092002) |
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| Research advancements of toll-like receptors and their relationships with autoimmune disorders |
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WU Jia-biao, REN Min
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Department of Hematology and Rheumatology,the Affiliated Wujin Hospital of Jiangsu University,Changzhou 213002，China
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| Abstract: |
| ［Abstract］ Toll-like receptors (TLRs) play a pivotal role in innate and adaptive immune responses. They recognise pathogens through signaling pathways. Accumulating evidence suggests TLRs are important in autoimmune disorders(SLE,RA). A greater understanding of the processes by which TLRs regulate adaptive immunity may yield new approaches to the treatment and prevention of autoimmune disorders. |
| Key words: Autoimmune disorders Toll-like receptors |
