| 摘要: |
| ［摘要］ 目的 探讨小剂量静注丙种球蛋白（LDIVIG）联合甲泼尼龙治疗难治性免疫性血小板减小性紫癜（RITP）的临床疗效。方法 选择20例住院病人，经激素或脾切除治疗无效者，应用LDIVIG 0.1 g·kg-1·d-1静脉滴注，连用5 d，同时口服甲泼尼龙片32 mg/d，观察治疗前后血小板（BPC）计数和黏膜、内脏等出血的临床表现。结果 治疗72 h后无出血症状，显效6例，良效4例，进步2例，无效8例，总有效率为60.0%。结论 LDIVIG联合甲泼尼龙治疗RITP疗效显著，可迅速减轻出血症状，是治疗RITP的有效途径之一。 |
| 关键词: 小剂量丙种球蛋白 甲泼尼龙 难治性免疫性血小板减少性紫癜 |
| DOI：10.3969/j.issn.1674-3806.2011.05.26 |
| 分类号:R 558 |
| 基金项目: |
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| Therapeutic effect of low dose of intravenous immune globulin combined with methylprednisolone in the treatment of refractory immunologic thrombocytopenic purpura |
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SU Shi-yong
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Department of Hematology, the Second People′s Hospital of Qinzhou City,Guangxi 535000,China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical therapentic effect of low dose of intravenous immune globulin (LDIVIG) combined with methylprednisolone in the treatment of refractory immunologic thrombocytopenic purpura(RITP).Methods Twenty inpatients with RITP,who did not respand to hormone therapy and splenectomy,were trented with intravenous drip of LDIVIG 0.1 g·kg-1·d-1 and oral administration of methylprednisolone tablets for 5 days,the blood pletelet count were recorded and the clinical manifestation of mucosal and visceal hemorrhage were observed before and affer treatment.Results The symptoms of hemorrhage disappeared 72 hours afler treatment,of them marked effect were found in 6 patients,good effect in 4 patients,improvement effect in 2 patients,no effect in 8 patients.The total effective rate was 60%.Conclusion The therapentic effect of LDIVIG combined with methylprednisolone in the treatment of RITP is significant.This therpy can quickly reduce symptom of hemorrhage,and is an effective way to treat RITP. |
| Key words: Low dose of intravenous immune globulin Methylprednisolone Refractory immunologic thrombocytopenic purpura(RITP) |
