| 摘要: |
| ［摘要］ 目的 观察谷氨酰胺颗粒干预重度慢性乙型病毒性肝炎内毒素血症的临床疗效。方法 将60例重度慢性乙型病毒性肝炎内毒素血症患者随机分成对照组和治疗组，每组30例。对照组采用常规护肝、抗病毒治疗，而治疗组在对照组治疗方案的基础上加用谷氨酰胺颗粒10 g，3次/d，疗程为2周。观察治疗前后两组患者的血清内毒素、肝功能的变化以及治疗后的总有效率。结果 治疗组总有效率（83.3%）优于对照组（50.0%），差异有统计学意义（P<0.01）。两组肝功能、血清内毒素较治疗前均有不同程度好转，治疗组与对照组比较差异有统计学意义（P<0.05或P<0.01）。结论 谷氨酰胺颗粒治疗重度慢性乙型病毒性肝炎内毒素血症是一种有效的辅助治疗方法。 |
| 关键词: 重度慢性乙型病毒性肝炎 谷氨酰胺颗粒 内毒素血症 肝功能 |
| DOI：10.3969/j.issn.1674-3806.2011.06.01 |
| 分类号:R 575.1 |
| 基金项目:广西自然科学基金资助项目（编号：桂科回0639013）；广西卫生厅重点科研课题（编号：桂卫重200810号） |
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| Observation of the effect of glutamine on endotoxemia in patients with severe chronic hepatitis B |
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GAO Meng, YANG Jian-rong, SONG Huai-yu, et al.
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First Clinical College of Guangxi Traditional Chinese Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the clinical effect of glutamine on endotoxemia in patients with severe chronic hepatitis B.Methods Sixty patients with severe chronic hepatitis B were randomly divided into control group(n=30) and treatment group(n=30). The patients were given regular treatment, including hepatic protectants and anti-virology therapy in control group. The patients were given extra glutamine 10 g Tid in addition to regular treatment in treatment group. The whole treatment duration lasted two weeks. Endotoxin (ET), liver function and the effective rate were compared between the two groups.Results The effective rate of the treatment group was 83.3% and that of the control group was 50.0%, which were significant difference (P<0.01). The total tests of liver function, serum endotoxin level showed positive changes in both of two groups (P<0.05 or P<0.01).Conclusion Adding glutamine to regular treatment is an effective adjuvant therapy for patients with severe chronic hepatitis B. |
| Key words: Severe chronic hepatitis B Glutamine Endotoxemia Liver function |
