| 摘要: |
| ［摘要］ 糖尿病肾病(diabetic nephropathy)是糖尿病的主要慢性并发症之一，已成为终末期肾功能衰竭的首位原因。肾功能主要由肾小球滤过率(renal glomerular filtration rate,GFR)反映。近年来相关临床试验已证明，血清胱抑素C(cystatin C,Cys C)与GFR有良好相关性，可以将其作为GFR的替代指标用于糖尿病肾病的诊断。Cys C是一种低分子量蛋白质,相对分子量小，是半胱氨酸蛋白酶抑制物超家族的成员之一，可由机体所有有核细胞产生，产生率恒定。循环中的Cys C能够自由通过肾小球滤过膜,并在近曲小管几乎完全被重吸收,不再重新回到血液循环中,同时,肾小管也不分泌Cys C，因此它是一种反映肾小球滤过率变化的理想的内源性标志物。Cys C测定的方法学也在不断发展，使血清Cys C测定在糖尿病肾病早期诊断的临床应用和推广成为可能。 |
| 关键词: 糖尿病肾病 肾小球滤过率 胱抑素C |
| DOI：10.3969/j.issn.1674-3806.2011.06.37 |
| 分类号:R 587.1 |
| 基金项目: |
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| Study progress on serum cystatin C in the early diagnosis of diabetic nephropathy |
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ZHAI Hong-yan, LONG Yan, SU Ke
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Department of Endocrinology, Affiliated Hospital Guilin Medical College, Guangxi 541001, China
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| Abstract: |
| ［Abstract］ Diabetic dephropathy is a major chronic complication of diabetes and has become the leading cause of end-stage renal failure, primarily reflected by renal glomerular filtration rate (GFR). In recent years, clinical trials have shown that serum cystatin C (Cys C) has good correlation with GFR,and Cys C can be used as a surrogate marker for the diagnosis of diabetic nephropathy. Cys C is a low molecular weight protein, and is a member of relatively small molecular weight cysteine proteinase inhibitor superfamily. Cys C is produced by all nucleated cells of the body, in constant rate. Cys C in circulationcan freely pass through the glomerular filtration membrane, and in the proximal tubule is reabsorbed almost completely, not return to the blood circulation, while Cys C is not secreted by renal tubules. So it is an ideal endogenous marker in reflecting the changes of GFR. The constant development of methodology for Cys C determination also makes application and promotion of serum Cys C in determination the early diagnosis possible. |
| Key words: Diabetic dephropathy Renal glomerular filtration rate(GFR) Cystatin C(Cys C) |
