| 摘要: |
| ［摘要］ 目的 探讨氧化应激在首发单一病灶脑卒中后抑郁患者的可能致病机制。方法 （1）将患者分为卒中后抑郁组和非抑郁组，分别行汉密尔顿抑郁量表评分及SOD、MDA、P-LPO、P-VitC、P-NO的检验。（2）卒中后抑郁组按抑郁程度又分为轻、中、重度抑郁患者，并比较它们之间的SOD值和MDA值。结果 （1）卒中后抑郁组SOD、P-LPO、P-NO值较非抑郁组增高，MDA、P-VitC值较非抑郁组低；（2）重度抑郁患者SOD值高于轻、中度抑郁患者（P<0.05），而MDA值低于轻、中度抑郁患者（P<0.05）。结论 （1）氧化应激效应可能参与了卒中后抑郁的发病机理；（2）重度抑郁组可能存在更剧烈的氧化应激反应。 |
| 关键词: 卒中后抑郁 氧化应激 |
| DOI：10.3969/j.issn.1674-3806.2011.07.04 |
| 分类号:R 743.3 |
| 基金项目:广西壮族自治区卫生厅自筹经费科研课题（编号：Z2008072） |
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| Study on oxidative stress of patients with a new single cerebral lesion accompanied by post-stroke depression |
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ZHANG De-min, WANG Rong-gui, ZHOU Li-yuan, et al.
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Department of Neurology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the relationship between oxidative stress and mechanism of post-stroke depression in patients with a new single cerebral lesion.Methods (1)The patients were divided into two groups, post-stroke depression(PSD) and non-PSD group. The level of plsama malonidialdehyde(MDA), the activity of superoxide dismutase(SOD), ascorbic acid(P-VitC), lipid peroxide(P-LPO), plasma nitric oxide(P-NO) were measured.(2)Based on Hamilton Depression Rating Scale, the patients were divided into these groups, mild depression, moderate depression, severe depression group and MDA, SOD level were compared among 3 groups.Results (1)Compared with non-PSD group, the SOD, P-LPO, P-NO level were higher in PSD group, but the MDA P-VitC level was lower.(2)Compared with mild depression group, and moderate group depression group, the SOD level was higher (P<0.05) and MDA level was lower(P<0.05) in severe depression group.Conclusion (1)Oxidative stress may be an important mechanism in post-stroke depression.(2)Severe depression group may have stronger oxidative stress. |
| Key words: Post-stroke depression Oxidative stress |
