| 摘要: |
| ［摘要］ 目的 研究子痫前期孕妇的血清可溶性血管内皮生长因子受体-1(sFlt-1)水平，以探讨其在子痫前期疾病发病中的作用及与妊娠结局的关系。方法 采用酶联免疫吸附试验(ELISA)检测78例子痫前期患者的外周静脉血sFlt-1水平,并与78例正常孕妇作对照。结果 子痫前期组的孕妇血清sFlt-1水平高于正常对照组，新生儿体重低于正常对照组，1 min Apgar评分在各组之间相比差异无统计学意义。孕妇血清sFlt-1水平与新生儿出生体重存在直线负相关关系(r=-0.69，P<0.01)。结论 子痫前期患者血清sFlt-1的改变，会引起内皮细胞激活和损伤，并对围产儿的结局产生不利影响。 |
| 关键词: 可溶性血管内皮生长因子受体-1 子痫前期 酶联免疫吸附测定 |
| DOI：10.3969/j.issn.1674-3806.2011.07.12 |
| 分类号:R 714.24 |
| 基金项目: |
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| Analysis of correlation between soluble fms-like tyrosine kinase-1 and preeclampsia |
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LIANG Li-li,CAI Chun-fang,WAN Bo,et al.
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Department of Obstetrics, Boai Hospital of Zhongshan City, Guangdong 528400, China
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| Abstract: |
| ［Abstract］ Objective To study the effect of soluble fms-like tyrosine kinase-1(sFlt-1) on preeclampsia.Methods The level of sFlt-1 in 70 patients with preedclampsia was measured by enzyme linked immunosorbent assay and compared with control group.Results The level of sFlt-1 was higher and the weight of neonate was lower in patients with preedclampsia than that in control group. No significant differences was found in 1 minute Apgar Score between two groups. A negative linear correlation between the level of sFlt-1 and the weight of neonate was found( r=-0.69; P<0.01).Conclusion The increase of sFlt-1 in patients with preeclampsia can activate and damage endothelial cells which has a harmful effect on fetus. |
| Key words: Soluble fms-like tyrosine kinase-1 Preeclampsia Enzyme linked immunosorbent assay |
