| 摘要: |
| ［摘要］ 目的 探讨围绝经期妇女重度抑郁症综合康复治疗的临床疗效。方法 对26例围绝经期重度抑郁症妇女给予服用尼尔雌醇、氟西汀、解郁汤及心理治疗，采用汉密尔顿抑郁量表(HAMD)和自评抑郁量表（SDS）评分进行治疗前后对比观察和治疗效果评价，同时检测血清雌二醇（E2）、血清促卵泡素（FSH）含量变化。结果 经过8周的综合康复治疗后，患者E2水平明显增高(P<0.01)，FSH含量显著降低(P<0.01)，HAMD和SDS评分明显降低(P<0.01)。26例患者经治疗后，治愈16例（61.5%），显效6例（23.1%），有效4例（15.4%），总有效率为100%。结论 综合康复治疗围绝经期妇女重度抑郁症疗效好、副作用小，是安全有效的治疗方法。 |
| 关键词: 围绝经期 抑郁症 尼尔雌醇 氟西汀 解郁汤 心理治疗 |
| DOI：10.3969/j.issn.1674-3806.2011.09.15 |
| 分类号:R 749.4 |
| 基金项目: |
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| Analysis of the clinical effect of comprehensive rehabilition therapy in the treatment of peri-menopausal women with severe depression |
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LUO Hong-ling, LI Xue
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Department of Gynecology and Obstetrics, Tiane People′s Hospital,Guangxi 547300, China
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| Abstract: |
| ［Abstract］ Objective To explore the effect of comprehensive rehahilitation therapy (famale hormone, anti-depression medicines, Chinese medicines and psychological interference) in the treatment of peri-menopausal women with severe depression. Methods Twenty-six peri-menopausal women with severe depression were treated with nilestriol, fluoxetine, Jieyu decoction and psychotherapy. All patients were evaluated by HAMD, SDS score before and after treatment. Serum E2,FSH were tested at the same time. Results After 8 weeks of comprehensive rehabilitation therapy, serum E2 levels significantly increased, serum FSH levels significantly decreased. HAMD scores and SDS scores were decreased significantly (P<0.01). The results showed that 61.5% (16/26) of patients were cured, the excellent rate and effective rate were 23.1% (6/26) and 15.4% (4/26) respectively. Conclusion It is suggested that comprehensive rehabilitation therapy is a safe and effective therapeutic method with less side effect in treating peri-menopausal women with severe depression. |
| Key words: Peri-menopausal period Depression Nilestriol Fluoxetine Jieyu decoction Psychotherapy |
