| 摘要: |
| ［摘要］ 目的 探讨肝脏血流灌注情况对肝硬化程度的鉴别诊断价值。方法 采用螺旋CT灌注成像检测20例肝硬化患者［属肝功能Child-Pugh分级A级7例定为肝硬化（1）组；肝功能Child-Pugh分级B级9例和C级4例定为（2）组］和15例正常对照者肝脏血流动力学变化。CT灌注扫描成像获取肝脏早期动态增强斜率值（Steep Slope,SS）函数曲线，分析曲线类型，并以脾增强高峰出现为界，把肝脏增强分为肝动脉期和门静脉期，计算肝动脉期和门静脉期最大斜率比值，记为SSr，作为评估指标进行组间对比。结果 （1）肝硬化1组、肝硬化2组及正常对照组三组斜率曲线类型分布存在差异（P<0.01）；（2）肝硬化患者SSr值较正常对照组加大，肝硬化1组与正常对照组比较差异无统计学意义（P>0.05），而肝硬化2组与正常对照组比较差异有统计学意义（P<0.01）；（3）肝硬化2组和肝硬化1组比较，肝硬化2组SSr值出现倒置，两组比较差异有统计学意义（P<0.01）。结论 早期动态CT增强动门脉斜率函数曲线类型及Steep Slope比值SSr能够反应肝硬化的血流灌注情况及血管变化程度，可作为肝硬化程度的定量指标，对评估临床治疗效果及预后具有重要价值。 |
| 关键词: 肝硬化 灌注成像 体层摄影术 X线计算机 |
| DOI：10.3969/j.issn.1674-3806.2012.02.12 |
| 分类号:R 575.2 |
| 基金项目: |
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| Study of multi-slice spiral CT perfusion imaging for detection of haemodynamics in the diagnosis of liver cirrhosis |
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WEI Hong-xing，PAN Qi-zhong, SU Guang-lin, et al.
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Department of Radiology,the People′s Hospital of Tiandeng,Guangxi 532800, China
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| Abstract: |
| ［Abstract］ Objective To study the differential diagnosis value of CT perfusion in patients with hepatic cirrhosis.Methods Twenty patients with hepatic cirrhosis and 15 volunteers underwent CT perfusion for detection of haemodynamics. Seven patients with hepatic cirrhosis belonged to cirrhosis group 1（Child-Pugh A），13 patients with hepatic cirrhosis belonged to cirrhosis group 2 （9 patients with hepatic cirrhosis were Child-Pugh B and the other 4 were Child-Pugh C）. Taking the liver dynamic enhanced steep slope(SS) curve by CT perfusion, and the type of curve was analyzed. The perfusion curves of hepatic parenchyma were separated into two part of arterial phase and venous phase according to the TTP of spleen, the max slope ratio of arterial phase and venous phase was calculated, signed to SSr, then SSr were compared between the 3 groups.Results （1）the type of SS curve was different between the 3 groups (P<0.01); (2)the SSr of cirrhosis groups were higher than that of normal group, but the difference was not significant between cirrhosis group 1 and normal group (P>0.05), but the difference was significant between cirrhosis group 2 and normal group (P<0.01)；（3）the SSr of cirrhosis group 2 were significantly higher than cirrhosis group 1，the SSr of cirrhosis 2 was inversed ，the difference between two groups was significant （P<0.01）.Conclusion The liver dynamic enhanced SS curve and SSr can reflect the blood flow of cirrhosis and the level of vascularization, be regarded as an indexes to evaluate the cirrhosis degree, and is a valuable important imaging in clinic. |
| Key words: Liver cirrhosis Perfusion imaging Tomography X-ray computed |
