| 摘要: |
| ［摘要］ 目的 探讨早期测定血清可溶性髓系细胞触发受体-1(sTREM-1)在诊断急性加重期慢性阻塞性肺疾病（AECOPD）患者合并肺部细菌感染中的价值。方法 应用定量酶联免疫吸附法(ELISA)检测60例AECOPD患者的血清sTREM-1水平，并将sTREM-1水平与临床肺部感染评分（CPIS）进行相关性分析。结果 AECOPD在细菌感染组血清sTREM-1水平明显高于无细菌感染组（P均<0.05）。根据ROC曲线,sTREM-1曲线下面积为0.930,95%可信区间为0.840～1.020，诊断效能好。且与CPIS评分呈正相关(r=0.246，P<0.05)。结论 早期测定血清sTREM-1水平对AECOPD患者合并肺部细菌感染的诊断有一定价值，可以为病情或感染严重程度的评估提供有意义的参考指标。 |
| 关键词: 慢性阻塞性肺疾病 可溶性髓系细胞触发受体-1 临床肺部感染评分 |
| DOI：10.3969/j.issn.1674-3806.2012.03.10 |
| 分类号:R 563.5 |
| 基金项目: |
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| The changes of serum soluble triggering receptor expressed on myeloid cell-1 level in AECOPD patients and its clinical significance |
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CHEN Hui-peng
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Department of Respiratory Diseases,the People′s Hospital of Liangjiang City,Guangdong 524400,China
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| Abstract: |
| ［Abstract］ Objective To explore the value of serum soluble triggering receptor expressed on myeloid cell-1(sTREM-1) in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease(AECOPD) patients with lung bacterial infection.Methods The sTREM-1 level was detected by ELISA method and the further relevant analysis between sTREM-1 level and clinical lung infection score (CPIS) was performed.Results The level of sTREM-1 in bacterial infection group was significantly higher than that in no bacterial infections group (P<0.05). According to the ROC curves of sTREM-1, AUC was 0. 930, 95%CI ranged from 0.840 to 1.020, the efficiency of diagnosis was prominent. And level of sTREM-1 had of the positive correlation with CPIS score (r=0.246, P<0.05).Conclusion The early determination of the level of sTREM-1 has certain value in diagnose of AECOPD patients with pulmonary bacteria infection, and provide positive reference for evaluating severity of illness or infection. |
| Key words: Chronic obstructive pulmonary disease(COPD) Soluble triggering receptor expressed on myeloid cell-1(sTREM -1) Clinical lung infection score(CPIS) |
