| 摘要: |
| ［摘要］ 目的 探讨脂蛋白（a）（Lp-a）在冠心病发生和发展中的作用。方法 同期测定34例急性心肌梗死（AMI）、123例非心肌梗死冠心病和163例非冠心病病人血清Lp-a浓度。结果 AMI组、非心肌梗死冠心病组、非冠心病组血清Lp-a浓度分别为（51.17±41.99）mg/dl、（28.90±29.61）mg/dl、（12.54±8.50）mg/dl，三组差异有统计学意义（P<0.01）。非心肌梗死冠心病组中，局限性狭窄亚组、弥漫性狭窄亚组血清Lp-a浓度分别为（22.84±3.73）mg/dl、（33.33±3.66）mg/dl，轻度狭窄亚组、中度狭窄以上亚组Lp-a水平分别为（22.04±3.25）mg/dl、（31.74±3.49）mg/dl，每两组间差异均有统计学意义（P<0.05）。结论 血清Lp-a浓度升高可能促进冠心病的发生和发展，随冠状动脉病变程度加重而依次升高，是冠心病的危险因素。 |
| 关键词: 冠状动脉疾病 冠心病 脂蛋白（a） |
| DOI：10.3969/j.issn.1674-3806.2012.04.08 |
| 分类号:R 541.4 |
| 基金项目: |
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| Discussion on correlation between lipoprotein （a） and colonary heart disease |
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HUANG Xian-nan, LAN Jing-sheng, LIU Yan, et al.
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Department of Cardiovascular Diseases, Affiliated Hospital of Youjiang Medical College for Nationality,Guangxi 533000,China
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| Abstract: |
| ［Abstract］ Objective To study the effect of lipoprotein(a)(Lp-a) in the occunence and development of coronary heart disease.Methods The serum Lp-a concentration in 34 cases of myocardial infarction (AMI),123 cases of non myocardial infarction coronary heart disease and 163 cases of non coronary heart disease were determined.Results Serum Lp-a concentration was （51.17±41.99）mg/dl,（28.90±29.61）mg/dl,（12.54±8.50）mg/dl in AMI group, non myocardial infarction coronary heart disease group and non coronary heart disease group respectively. There were statistical significant difference among the 3 groups （P<0.01）.In non coronary heart disease group, they were （22.84±3.73）mg/dl and （33.33±3.66）mg/dl in local narrow subgroup and diffuse narrow subgroup respectively. And （22.04±3.25）mg/dl and （31.74±3.49） mg/dl in mild narrow subgroup and moderate or more narrow subgroup. There were statistical significant difference between every two groups.Conclusion The increase of serum Lp-a concentration may promote the occurrence and development of coronary heart disease. The Lp-a concentration gradually increase with the increase of coronary artery pathological changes, and its increase may be a risk factor for coronary heart disease. |
| Key words: Coronary artery disease Coronary heart disease Lipoprotein(a)(Lp-a) |
