| 摘要: |
| ［摘要］ 随着分子生物学技术和医学遗传学的发展，产前诊断技术向早期、快速、准确、无创伤发展，使越来越多的出生缺陷能够在胚胎发育的较早期诊断出来。荧光原位杂交技术（FISH）是一种为遗传病诊断提供更直观、快速诊断的分子细胞遗传技术，随着DNA技术的发展与染色体特异性探针的出现，FISH技术越来越多应用于生殖医学领域的临床诊断。该文对FISH技术在快速产前诊断中的研究进展作一综述。 |
| 关键词: 荧光原位杂交 快速产前诊断 植入前遗传学诊断 |
| DOI：10.3969/j.issn.1674-3806.2012.04.36 |
| 分类号:R 714 |
| 基金项目: |
|
| Progress in the rapid prenatal diagnosis by using of fluorescence in situ hybridization |
|
MO Yao-xi, MO Wei-ying,TAN Yi
|
|
Reproductive Medical and Genetic Center, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ With fast development in molecular biology and medical genetics, prenatal diagnosis is becoming rapid,sensitive and non-invasive techniques, more and more birth defects has been diagnosed in early stage of embryonic development. With the advent of chromosome-specific probe and development of DNA technique, fluorescence in situ hybridization (FISH) has widely been used in clinical as a molecular diagnostic technology by providing intuitionistic and rapid diagnosis. In the paper, the research progresses of FISH in the rapid prenatal diagnosis are discussed. |
| Key words: Fluorescence in situ hybridization（FISH） Rapid prenatal diagnosis Preimplantation genetic diagnosis |
