| 摘要: |
| ［摘要］ 目的 探讨联合检测多种生化指标对高血压肾损害早期诊断的价值。方法 将入选的98例高血压患者分为A、B两组，A组为单纯高血压患者（n=50），B组为高血压合并有微量蛋白尿患者（n=48），同时选择56名健康体检者作为对照组，分别检测血清肌酐（Scr）、血清胱抑素C(Cys C)、尿β2微球蛋白(β2-MG)、尿N-乙酰-β-D-氨基葡萄糖苷酶(N-acetyl-β-D-glucosaminidase，NAG)四项指标。结果 三组Scr检测值比较差异无统计学意义（P>0.05）；A组、B组Cys C、β2-MG、NAG水平均明显高于对照组（P<0.01）,而B组Cys C、β2-MG、NAG水平明显高于A组（P<0.01）。由Cys C、β2-MG、NAG组成的生化标志组合对高血压肾损害早期的阳性诊断率达69.3%（68/98)，明显高于Cys C 36.7%（36/98)、β2-MG 28.5%（28/98)和NAG 33.6%（33/98）各单项检测（P<0.01）。结论 多种生化指标联合检测可较早地反映高血压肾功能受损程度，对高血压肾损害早期的诊断具较高的敏感性和临床意义。 |
| 关键词: 高血压 肾损害 联合检测 |
| DOI：10.3969/j.issn.1674-3806.2012.07.11 |
| 分类号:R 54 |
| 基金项目: |
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| The application of combined determination of a lot of biochemical index in early diagnosis of hypertensive renal damage |
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HE Dong-ming, FU Chun-hui, YAN Hua
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Department of Cardiology,the Second People Hospital of Qinzhou,Guangxi 535000,China
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| Abstract: |
| ［Abstract］ Objective To investigate the value of combined determination of a lot of biochemical index in early diagnosis of hypertensive renal damage. Methods Ninety-eight hypertension patients were divided into A group and B group. Hypertension patients without complication were used as group A (n=50), those with microalbuminuria were used as group B (n=48), and 56 healthy persons were used as control group. Scr, Cys-C, β2-MG, N-acetyl-β-D-glucosaminidase (NAG) were measured respectively.Results Scr had no significant difference among the three groups(P>0.05),and the levels of Cys-C, β2-MG and NAG in group A and B was higher than those in control group(P<0.01), and the levels of Cys-C, β2-MG and NAG in group B was higher than those in group A (P<0.01).The positive diagnosis rate of combined determination of Cys-C、β2-MG and NAG in early diagnosis of hypertensive renal damage can reach 69.3%(68/98), which was higher than Cys-C 36.7%(36/98), β2-MG 28.5%(28/98) and NAG 33.6%(33/98) which was detected by single index(P<0.01).Conclusion Combined determination of blood and urine can reflect hypertensive renal functional lesion early, and have high sensitivity and clinical significance in early diagnosis of hypertensive renal damage. |
| Key words: Hypertension Renal damage Combined determination |
