| 摘要: |
| ［摘要］ 目的 探讨行重组人p53腺病毒（rAd-p53）瘤内注射前后鼻咽癌原发灶中淋巴管的表达情况。方法 63例确诊中晚期鼻咽癌患者随机分为两组。治疗组32例行rAd-p53瘤内注射+同步放化疗，对照组31例行单纯同步放化疗。分别收集两组的临床资料，采集rAd-p53瘤内注射前后鼻咽部瘤体活组织标本，采用免疫组化二步法检测鼻咽癌原发灶组织中淋巴管D2-40的表达情况。结果 两组D2-40蛋白表达差异无统计学意义（P>0.05）。两组治疗后D2-40蛋白表达均较治疗前升高，差异有统计学意义（P<0.01）。结论 rAd-p53可能通过某种机制抑制鼻咽癌淋巴道转移。 |
| 关键词: 鼻咽癌 rAd-p53 淋巴管 |
| DOI：10.3969/j.issn.1674-3806.2012.09.05 |
| 分类号:R 739.63 |
| 基金项目:广西卫生厅科研课题（编号：Z2008043）；广西医疗卫生重点科研课题（编号：重200721） |
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| Effect of intratumoral injection of rAd-p53 on lymphangiogensis in nasopharyngeal carcinoma |
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JIANG He, LAN Gui-ping,WENG Jing-jin,et al.
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Department of Otolaryngology Head and Neck Oncology, the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To evaluate the expression of lymphatic vessels of in primary foci of nasopharyngeal carcinoma(NPC) after intratumoral injection of recombinant human p53 adenovirus (rAd-p53).Methods Sixty-three patients with advanced nasopharyngeal carcinoma were randomly divided into 2 groups. Treatment group (n=32) received rAd-p53 intratumoral injection,concurrent radiotherapy and chemotherapy. The control group (n=31) received concurrent radiotherapy and chemotherapy. Clinical data were collected, and before and after intratumoral injection of rAd-p53 nasopharyngeal tumor biopsy specimens were collected. Two-step immunohistochemical detection was used to test D2-40 expression in primary foci of NPC.Results After treatment,D2-40 expression was significantly higher than that before treatment in two groups(P<0.05 or P<0.01). The difference of D2-40 expression between two groups was not statistically significant (P>0.05).Conclusion rAd-p53 may inhibite lymph node metastasis of nasopharyngeal carcinoma by some mechanism. |
| Key words: Nasopharyngeal carcinoma rAd-p53 Lymphatic vessels |
