| 摘要: |
| ［摘要］ 目的 探讨牛磺酸对体外冲击波碎石术（ESWL）致肾脏损伤的保护作用及机制。方法 将60例肾结石患者按半随机法分成牛磺酸组和对照组，每组30例。于ESWL前1 d开始分别口服牛磺酸粉和安慰剂2 g/次，3次/d，共7 d，术前及术后1 d、3 d、7 d测定患者尿微量白蛋白(ALB)、β2-微球蛋白(β2-MG)、内皮素-1(ET-1)及丙二醛(MDA)的变化。结果 冲击前两组尿ALB、β2-MG、ET-1、MDA比较差异无统计学意义（P>0.05）。对照组冲击后1 d、3 d尿ALB、β2-MG、ET-1、MDA均显著升高，与牛磺酸组相比，差异均有统计学意义（P<0.001）。结论 牛磺酸对ESWL致肾损伤有保护作用，其保护机制可能与其抗氧化作用和抑制ET-1生成有关。 |
| 关键词: 体外冲击波碎石术 肾脏损伤 牛磺酸 |
| DOI：10.3969/j.issn.1674-3806.2012.11.07 |
| 分类号:R 692 |
| 基金项目:广西自然科学基金资助项目(编号：桂科青0728036) |
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| Protective effects of taurine on renal injury induced by extracorporeal shock wave lithotripsy |
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LAN Zhi-xiang, LIU Gang,FU Qiang,et al.
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Department of Urology,the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To evaluate the protective effect of taurine on renal injury induced by extracorporeal shock wave lithotripsy(ESWL).Methods Sixty patients with kidney stones were divided into the taurine group(n=30) and the control group (n=30) at random. The two groups were respectively given 6g taurine and 6g placebo each day from the day before the ESWL to 6th day after the ESWL. The urinary samples were taken on the preoperative day and 1th,3th,7th day after the ESWL for determination of albumin (ALB),β2-microglobulin(β2-MG), endothelin (ET-1) and malondialdehyde (MDA).Results There were no significant difference between the two groups of urinary ALB, β2-MG, ET-1, MDA before the ESWL（P>0.05）. In the control group,the indexs were significantly elevated on the 1th,3th day after the ESWL compared with pre-treatment and the taurine group（P <0.001）.Conclusion Taurine is effective in the protection of kidney against injury induced by ESWL.The mechanism may be related with its antioxidation capability and inhibition of ET-1 generation in kidney. |
| Key words: Extracorporeal shock wave lithotripsy Kidney damage Taurine |
