| 摘要: |
| ［摘要］ 目的 探讨肿瘤标志物神经特异性烯醇化酶（NSE）、细胞角蛋白（CYFRA21-1）、癌胚抗原（CEA）、糖类抗原125（CA125）对肺癌的诊断价值。方法 用电化学发光法分别检测70例肺癌、50例肺良性疾病患者及50名正常人的血清NSE、CYFRA21-1、CEA、CA125的含量并进行分析。结果 三组4种肿瘤标志物检测比较差异有统计学意义（P均<0.01）；肺癌组患者NSE、CYFRA21-1、CEA、CA125水平高于良性肺疾病患者和健康人（P均<0.01）。血清中NSE在小细胞肺癌中水平高于其他类型肺癌（P均<0.01），CYFRA21-1在鳞癌中水平高于其他类型肺癌（P均<0.05）；单项NSE灵敏度最高为87.14%，联合检测以任一阳性时，灵敏度最高达98.57%，优于单项检测；NSE、CYFRA21-1、CEA灵敏度分别在小细胞肺癌、鳞癌、腺癌中最高。结论 肿瘤标志物NSE、CYFRA21-1、CEA、CA125对肺癌的辅助诊断、鉴别诊断和分型有非常重要的临床意义。 |
| 关键词: 肺癌 肿瘤标志物 诊断价值 |
| DOI：10.3969/j.issn.1674-3806.2012.11.10 |
| 分类号:R 734.2 |
| 基金项目: |
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| Diagnostic value of the combined detection of serum tumor markers in patients with lung cancer |
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HE Wang-jiao
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Department of Clinical Laboratories,Liuzhou Worker′s Hospital,Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou 545005,China
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| Abstract: |
| ［Abstract］ Objective To investigate the diagnostic value of serum tumor markers neuron specific enolase (NSE),tokeratin 19 fragment (CYFRA21-1), carcinoembryonic antigen (CEA),carbohydrate antigen (CA125) in lung cancer.Methods The NSE,CYFRA21-1,CEA,CA125 contents of 70 cases of lung cancer,50 cases of benign disease and 50 cases of healthy controllers were detected by electrochemiluminescence immunoassay(ECLIA) and analyzed.Results In comparison of 4 tumor markers among three groups,the difference was statistically significant (all P<0.01). The average of the NSE,CYFRA21-1,CEA,CA125 of lung cancer group were higher than those of benign lung disease and healthy controllers (all P<0.01). The level of NSE in patients with small cell lung cancer was higher than those of other subtypes (all P<0.01). The level of CYFRA21-1 in patients with squamous cell carcinoma was higher than those of other subtypes (all P<0.05). The sensitivity of NSE were most high in four tumor markers,which was 87.14%.The sensitivity of the combined detection of more than one of the four tumor markers were most high,which was 98.57%, which was superior to signal assay. The sensitivity of NSE in small cell lung cancer was higher than those of other subtypes. The sensitivity of CYFRA21-1 in squamous cell carcinoma was higher than those of other subtypes. The sensitivity of CEA adenocarcinoma was higher than those of other subtypes.Conclusion Tumor markers NSE,CYFRA21-1,CEA,CA125 for lung cancer diagnosis,differential diagnosis and classification has very important clinical significance. |
| Key words: Lung cancer Tumor marker Diagnostic value |
