摘要: |
[摘要] 原发性肝癌(HCC)是世界最常见严重危害人群身心健康和生命安全的恶性肿瘤之一,其发病机制至今尚不明确。8-羟基脱氧鸟苷(8-OHdG)是活性氧自由基(ROS)造成的DNA氧化损伤修饰性产物之一,研究表明,8-OHdG与HCC发生发展有着很大的关联。该文对8-OHdG与HCC发生发展的研究现状进行综述。 |
关键词: 原发性肝癌 8-羟基脱氧鸟苷 氧化损伤 |
DOI:10.3969/j.issn.1674-3806.2013.03.34 |
分类号:R 115 |
基金项目: |
|
Advances of 8-hydroxy-2’-deoxyguanosine expression in primary hepatocellular carcinoma |
TANG Yi,LIU Li-li,TANG Yun-tian
|
Guangxi Medical University, Nanning 530021, China
|
Abstract: |
[Abstract] Primary hepatocellular carcinoma(HCC)is one of the most common malignant tumors which is serious threatening people’s health,and its pathogenesis is still unclear so far. Research shows that 8-hydroxy-2′-deoxyguanosine(8-OHdG) play an important role in the carcinogenesis mechanism and development of HCC as the representative product of oxidative DNA damage.This paper reviews the present advances of research on 8-OHdG expression in HCC. |
Key words: Primary hepatocellular carcinoma 8-hydroxy-2′-deoxyguanosine Oxidative DNA damage |