| 摘要: |
| ［摘要］ 目的 探讨2型糖尿病(T2DM)并发脑梗死患者血清高半胱氨酸(Hcy)和非高密度脂蛋白胆固醇(non-HDL-C)的水平及临床意义。方法 选取132例脑梗死患者根据是否伴有T2DM分为T2DM组49例,非糖尿病组83例,并与健康人对照组58名比较。分别测定Hcy、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C），计算出non-HDL-C。结果 三组间六项指标差异均有统计学意义（P<0.01），T2DM并发脑梗死组、非糖尿病并发脑梗死组患者血清Hcy、TG水平显著升高,HDL-C显著降低（P<0.01）;T2DM组non-HDL-C显著高于健康人对照组（P<0.01）。T2DM并发脑梗死患者的血清TC、TG、LDL-C、non-HDL-C水平显著高于非糖尿病组（P<0.05）。脑梗死患者的Hcy与血脂无相关性;non-HDL-C与TC、TG和LDL-C呈正相关。结论 T2DM并发脑梗死患者血清Hcy、non-HDL-C水平显著升高,可以作为T2DM并发脑梗死风险预测以及降糖、降脂治疗效果评估的指标。 |
| 关键词: 糖尿病 脑梗死 高半胱氨酸 非高密度脂蛋白胆固醇 |
| DOI：10.3969/j.issn.1674-3806.2013.04.17 |
| 分类号:R 587.1 |
| 基金项目: |
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| Detection of homocysteine and non-high density lipoprotein cholesterol in diabetes patients with cerebral infarction and its clinical significance |
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LV Jun,LV Mei,CHEN Si-jia
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Department of Laboratory Medicine,the People’s Hospital of Yongcheng City,Henan 476600,China
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| Abstract: |
| ［Abstract］ Objective To analyze the concentration and significance of homocysteine and non-high density lipoprotein cholesterol in diabetes patients with cerebral infarction.Methods One hundred and thirty-two patients with cerebral infarction were divided into two groups: 49 patients in T2DM group, 83 patients in non-diabetic group, with 58 healthy people as normal control group.Determination of Hcy,TC,TG,HDL-C,LDL-C were performed, the non-HDL-C was calculated.Results There were statistically significant different in above six indexes among three groups（P<0.01）.The level of serum Hcy， TG in T2DM group and non-diabetic group were significantly increased, the level of HDL-C significantly reduced（P<0.01）; the level of non-HDL-C in T2DM group were significantly higher than that in healthy control group（P <0.01）.The level of serum TC,LDL-C and non-HDL-C in T2DM group were significantly higher than those in non-diabetic group（P<0.05）. No relationship was found between Hcy and blood lipid in patients with cerebral infarction; non-HDL-C was positively correlated with TC,TG and LDL-C.Conclusion The level of serum Hcy,non-HDL-C in T2DM patients with cerebral infarction were significantly increased, which can be used as cerebral infarction risk prediction and effectiveness evaluation index of glucose-lowering and lipid-lowering treatment. |
| Key words: Diabetes Cerebral infarction Homocysteine Non-high density lipoprotein cholesterol |
