| 摘要: |
| ［摘要］ 目的 探讨米索前列醇直肠给药预防剖宫产产后出血的临床疗效。方法 选择2011-01～2011-12有发生产后出血高危因素的剖宫产产妇220例，随机分为实验组和对照组各110例。两组均于剖宫产胎儿娩出后产妇常规宫体肌层注射缩宫素20 U，同时静脉滴注缩宫素20 U，而实验组则在术毕清除阴道积血后肛塞米索前列醇400 μg，深度达4～5 cm。观察两组术后2 h、24 h阴道出血量以及用药后血压、心率、药物不良反应。结果 实验组术后2 h及24 h出血量显著少于对照组（P<0.01）。两组产妇用药前后血压、心率、呼吸及药物不良反应发生率比较差异无统计学意义（P均>0.05）。结论 应用米索前列醇直肠给药预防剖宫产产后出血效果明显，值得临床推广应用。 |
| 关键词: 米索前列醇 催产素 剖宫产术 产后出血 |
| DOI：10.3969/j.issn.1674-3806.2013.04.19 |
| 分类号:R 714 |
| 基金项目: |
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| Efficacy of rectal administration of misoprostol in the prevention of postpartum hemorrhage after cesarean section |
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LIU Wei-wu
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Department of Obstetrics,Maternal and Children Health Hospital of Yulin,Guangxi 537000,China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical efficacy of rectal administration of misoprostol in prevention of postpartum hemorrhage after cesarean section.Methods From January 2011 to December 2011, Two hundred-twenty parturient women with postpartum hemorrhage risk factors for cesarean section were randomly divided into experimental group and control group with 110 cases in each group. In both groups oxytocin 20 U was injected into the uterine body of parturient women after the baby was delivered during cesarean section, at the same time intravenous infusion of oxytocin 20 U was performed. In the experimental group at the end of surgery and after removing vaginal hemorrhage, misoprostol 400 μg was placed at depth of 4～5 cm within the rectum. At 2 h and 24 h after operation,vaginal bleeding were observed and the blood pressure, heart rate, and adverse drug reactions after drug administration were observed.Results At 2 h and 24 h after operation blood loss in the experimental group was significantly less than that in the control group(P<0.01). Before and after treatment,between the two groups there was no statistically significant difference in maternal blood pressure, heart rate, breathing, and the incidence of adverse drug reactions(P>0.05).Conclusion Rectal administration of misoprostol in the prevention of postpartum hemorrhage after cesarean section has better efficacy and is worthy of promotion. |
| Key words: Misoprostol Oxytocin Cesarean section Postpartum hemorrhage |
