| 摘要: |
| ［摘要］ 自身抗体是指抗自身细胞内、细胞表面和细胞外抗原的免疫球蛋白，是自身免疫和自身免疫性疾病重要特征之一。抗核抗体是指抗细胞内所有抗原成分的自身抗体的总称，某些自身免疫性疾病伴有特征性的自身抗体谱，而疾病标记性抗体或特异性抗体可诊断和鉴别诊断疾病特性。自身抗体可判断疾病的活动性及预后，观察治疗反应，指导临床治疗。进一步的抗核抗体谱研究，可阐明抗核抗体与自身免疫性疾病的相关性。该文对抗核抗体谱及其靶抗原与疾病的相关性进行了综述。 |
| 关键词: 自身抗体 自身免疫性疾病 抗核抗体谱 抗核抗体荧光模型 抗核抗体滴度 |
| DOI：10.3969/j.issn.1674-3806.2013.08.32 |
| 分类号:R 446.1 |
| 基金项目:广西贺州市科学研究与技术开发计划项目课题（编号:贺科转120904） |
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| New progress study of antinuclear antibodies |
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LI Yan-mei,TAN Yi
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Department of Clinical Laboratory，Guidong People′s Hospital, Guangxi 543001,China
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| Abstract: |
| ［Abstract］ Autoantibodies refer to the resistance of immune globulins to their own intracellular antigens, the cell surface antigen and the extracellular antigen; They are one of the key characteristics for autoimmune and autoimmune diseases. Antinuclear antibodies are the total autoantibodies of intracellular antigenic components. Some autoimmune diseases contain characteristic autoantibodies. The marked autoantibodies or special autoantibodies can be used for diagnosis and differential diagnosis of the disease characters. Autoantibodies can be estimated for activity and prognosis of diseases, responsed to therapies, and guided for clinic treatment as well. Further antinuclear antibody spectrum research can clarify the relationship between the antinuclear antibodies and autoimmune diseases. Thus, this paper clarifies the relationship between antinuclear antibody, auto antigen and diseases. |
| Key words: Autoantibody Autoimmune disease Antinuclear antibody spectrum Antinuclear antibody fluorescence model Antinuclear antibody titer |
