| 摘要: |
| ［摘要］ 同型半胱氨酸（homocystein，HCY）是蛋氨酸脱甲基产生的中间代谢物，通常血浆HCY水平在10 μmol/L以上称为高同型半胱氨酸血症（HHCY）。H型高血压是指血浆HCY水平在10 μmol/L以上的原发性高血压。高血压、高HCY双重危险因素显著增加了心脑血管事件风险。该文综述了H型高血压的定义、HCY的代谢途径、HCY在血浆中的存在形式以及H型高血压的临床意义和防控策略的研究进展，以期提高对H型高血压的关注，并最终降低心脑血管事件风险。 |
| 关键词: H型高血压 同型半胱氨酸 高同型半胱氨酸血症 控制策略 |
| DOI：10.3969/j.issn.1674-3806.2013.11.33 |
| 分类号:R 544.1 |
| 基金项目: |
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| Research advance of H-type hypertension |
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CHEN Wen-bo,TAN Yi
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Intensive Care Unit,the People′s Hospital of Hanshou County,Hunan 415900,China
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| Abstract: |
| ［Abstract］ Homocystein(HCY)is the product of intermediary metabolism of methionine demethylation. Usually,the level of plasma HCY exceeding 10 μmol/L is called hyper-homocysteinemia(HHCY). The essential hypertension with HHCY is defined as H-type hypertension. Hypertension and HHCY as double risk factors significantly increased the risk of cardiovascular and cerebrovascular events. This paper provides an overview of the definition of H-type hypertension, the metabolic pathways of HCY, existence forms of HCY in the plasma,clinical significance and control strategy of H-type hypertension, in order to improve cognition and attention on H-type hypertension and eventually reduce the risks of cardiovascular and cerebrovascular events. |
| Key words: H-type hypertension Homocystein Hyper-homocysteinemia Control strategy |
