| 摘要: |
| ［摘要］ 目的 探讨高初始浓度七氟烷吸入诱导全身麻醉的安全性和有效性。方法 选取择期手术全麻的成年患者300例，ASAⅠ～Ⅱ级，按手术日期单双号半随机分为两组，均予七氟烷麻醉诱导。低初始浓度组179例，最初给予低的初始浓度（0.5%），然后逐渐增加剂量，直到病人被麻醉。高初始浓度组121例，开始即给予高浓度(4%～8%)，直到病人被麻醉。两种方法均可使用不同呼吸模式，记录睫毛反射消失时间和不良反应发生例数。结果 高初始浓度组睫毛反射消失时间明显短于低初始浓度组，差异有统计学意义（P<0.01）。两组的各种不良反应的发生率差异均无统计学意义（P>0.05）。结论 高初始七氟烷浓度与低初始浓度相比诱导时间更短，并发症发生率差异均无统计学意义，值得推广应用。 |
| 关键词: 七氟烷 麻醉诱导 不良反应 |
| DOI：10.3969/j.issn.1674-3806.2014.02.17 |
| 分类号:R 614.1 |
| 基金项目: |
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| High initial concentration sevoflurane for inhalational induction of general anaesthesia:a prospective research |
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CHEN Zu-tao,PENG Hui-li,WANG Peng
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Department of Anesthesia, Pingmei Shenma Medical Group General Hospital，Pingdingshan 467000，China
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| Abstract: |
| ［Abstract］ Objective To investgatd the safety and efficacy of the high initial concentration sevoflurane for inhalational induction of general anaesthesia.Methods Three hundred adult patients undergoing elective surgery anesthesia, ASAⅠ～Ⅱ, were randomly divided into two groups according to odd or even number of operative date.The low initial concentration group(179 cases) was initially administered a low concentration of sevoflurane then the concentration was gradually increased until the patient was anaesthetized. The high initial concentration group(121 cases) was administered high concentrations of sevoflurane(from 4% to 8%) from the beginning, continuing until the patients was anaesthetized. Both techniques can be carried out using different breathing patterns. Time to loss of eyelash reflex(LOER)(seconds), complication rates in the two groups were recorded.Results Time to LOER in high initial concentration group was obviously shorter than the lower initial concentration groups, the differences were statistically significant （P<0.01）.There was no difference in the incidence of adverse effects between the two groups（P>0.05）.Conclusion Compared with low initial concentration of sevoflurane a high initial concentration sevoflurane probably offers more rapid induction of anaesthesia and a similar rate of complications, especially worth promoting. |
| Key words: Sevoflurane Anesthetic induction Adverse effects |
