| 摘要: |
| ［摘要］ 多囊卵巢综合征（PCOS）是一种以高雄激素血症、排卵障碍以及多囊卵巢为特征的病变。其发病机制至今尚未阐明，目前研究方向主要在基因多态性领域，基因研究表明胰岛素作用、类固醇激素的合成与代谢、性激素功能失调、卵泡形成等相关影响基因以及慢性炎症因子均可能参与PCOS的发病机制。 |
| 关键词: 多囊卵巢综合征 基因 发病机制 多态性 |
| DOI：10.3969/j.issn.1674-3806.2014.03.31 |
| 分类号:R 737.31 |
| 基金项目: |
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| The advance on the relationship between genetic polymorphism and the pathogenesis of PCOS |
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LIU Min,WANG Lin
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Department of Obstetrics and Gynecology,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Polycystic ovary syndrome(PCOS) is characterized by hyperandrogenism,ovulatory dysfunction and polycystic ovary.The exact pathogenesis of PCOS remains elusive,present researches mainly focus on the field of genetic polymorphism.Genetic researches showed that the genes which were correlated with insulin effects, synthesis and metabolism of steroid hormone, dysfunction of gonadal hormone, folliculogenesis,chronic inflammatory factors, might contributed to PCOS pathogenesis. |
| Key words: Polycystic ovary syndrome(PCOS) Gene Pathogenesis Polymorphism |
